<p>In veterinary medicine, stem cells therapy is mostly used to treatment of orthopedic condition. Stem cell behavior is shaped by numerous intrinsic and extrinsic factors. Traditional medicinal herbs—long used to prevent and treat diverse diseases—together with other natural bioactive compounds have attracted increasing interest because of their potential to modulate stem cell function. Many of these agents exhibit antioxidant, anti-inflammatory, anticancer, and anti-apoptotic activities and may support tissue regeneration by enhancing proliferation, differentiation, and migration. Importantly, natural products may offer safer and more cost-effective alternatives to synthetic growth factors in regenerative strategies. Accordingly, this review summarizes recent evidence on medicinal plants, phytochemicals, algal extracts, and related bioactive compounds that influence veterinary stem cells, and discusses their potential applications in regenerative medicine.</p>