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<p>Premature ovarian failure (POF) is characterized by decreased ovarian function in women under 40 years of age, which leads to amenorrhea and infertility. This condition is commonly associated with diverse symptoms related to hormonal deficiency. The individuals with POF are also at an increased risk of developing several systemic conditions, including osteoporosis, neurological issues, and cardiovascular diseases. POF significantly impacts a woman’s reproductive health, fertility, and overall quality of life. The current treatments for POF primarily include hormone replacement therapy (HRT) and ovulation induction, although these approaches have significant limitations. Recent advances in relevant research have highlighted the therapeutic potential of microRNAs (miRNAs), which exhibit promising outcomes in preventing granulosa cell (GC) apoptosis, enhancing hormonal secretion, mitigating oxidative stress, and promoting angiogenesis. This review focuses on the significance of exosomal miRNAs in POF management, particularly their roles in preventing GC apoptosis and restoring ovarian function. The objective is to guide the future clinical trials and therapeutic applications and thereby advance the research in this field.</p>

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Potential MiRNA therapies for premature ovarian failure: new challenges and opportunities

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月15日

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  • Wang Xinyue,
  • Li Hongli,
  • Guo Chunhui,
  • Chen Jibing,
  • Yu Hua

摘要

Premature ovarian failure (POF) is characterized by decreased ovarian function in women under 40 years of age, which leads to amenorrhea and infertility. This condition is commonly associated with diverse symptoms related to hormonal deficiency. The individuals with POF are also at an increased risk of developing several systemic conditions, including osteoporosis, neurological issues, and cardiovascular diseases. POF significantly impacts a woman’s reproductive health, fertility, and overall quality of life. The current treatments for POF primarily include hormone replacement therapy (HRT) and ovulation induction, although these approaches have significant limitations. Recent advances in relevant research have highlighted the therapeutic potential of microRNAs (miRNAs), which exhibit promising outcomes in preventing granulosa cell (GC) apoptosis, enhancing hormonal secretion, mitigating oxidative stress, and promoting angiogenesis. This review focuses on the significance of exosomal miRNAs in POF management, particularly their roles in preventing GC apoptosis and restoring ovarian function. The objective is to guide the future clinical trials and therapeutic applications and thereby advance the research in this field.