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Background <p>High-intensity focused ultrasound ablation has emerged as a noninvasive therapeutic option for adenomyosis of the uterus. We studied a female with infertility patient to explore the application of <i>in vitro</i>&#xa0;fertilization combined with high-intensity focused ultrasound treatment in patients with endometriosis complicated by adenomyosis.</p> Case presentation <p>A retrospective analysis of a 30-year-old Han Chinese woman with infertility complicated by both endometriosis and adenomyosis was performed, including pregnancy achieved through <i>in vitro</i>&#xa0;fertilization, downregulation using a gonadotropin-releasing hormone agonist, high-intensity focused ultrasound treatment and final pregnancy outcomes. The patient successfully conceived following the combined application of high-intensity focused ultrasound treatment and downregulation using a gonadotropin-releasing hormone agonist, with an intrauterine pregnancy confirmed in June 2025 and appropriate fetal development.</p> Conclusion <p>The combined application of downregulation using a gonadotropin-releasing hormone agonist and high-intensity focused ultrasound treatment represents a promising therapeutic strategy for patients with infertility with concurrent endometriosis and adenomyosis. Nevertheless, prospective multi-centre studies remain essential to validate the long-term efficacy and safety profiles.</p>

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In vitro fertilization-assisted pregnancy combined with high-intensity focused ultrasound treatment in patients with endometriosis and adenomyosis with successful pregnancy: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月5日

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  • Qiuyue Wen,
  • Yaping Ma,
  • Jing Chen,
  • Yuan Ou,
  • Chunling Yao

摘要

Background

High-intensity focused ultrasound ablation has emerged as a noninvasive therapeutic option for adenomyosis of the uterus. We studied a female with infertility patient to explore the application of in vitro fertilization combined with high-intensity focused ultrasound treatment in patients with endometriosis complicated by adenomyosis.

Case presentation

A retrospective analysis of a 30-year-old Han Chinese woman with infertility complicated by both endometriosis and adenomyosis was performed, including pregnancy achieved through in vitro fertilization, downregulation using a gonadotropin-releasing hormone agonist, high-intensity focused ultrasound treatment and final pregnancy outcomes. The patient successfully conceived following the combined application of high-intensity focused ultrasound treatment and downregulation using a gonadotropin-releasing hormone agonist, with an intrauterine pregnancy confirmed in June 2025 and appropriate fetal development.

Conclusion

The combined application of downregulation using a gonadotropin-releasing hormone agonist and high-intensity focused ultrasound treatment represents a promising therapeutic strategy for patients with infertility with concurrent endometriosis and adenomyosis. Nevertheless, prospective multi-centre studies remain essential to validate the long-term efficacy and safety profiles.