Background <p>This case report presents the first documented instance of vaginal candidiasis linked to the intake of a hair, skin, and nails supplement.</p> Case presentation <p>A 64-year-old Caucasian female patient, with a history of chronic kidney disease and multiple comorbidities, developed symptoms of vaginal yeast infection after beginning the supplement. The adverse event was evaluated using the Naranjo Adverse Drug Reaction Probability Scale, scoring a 5, indicating a probable association. Despite extensive literature searches, no similar cases were found, suggesting this might be a unique reaction. This report highlights potential safety concerns with dietary supplements, particularly those not regulated by the Food and Drug Administration, underscoring the need for further investigation into their adverse effects.</p> Conclusions <p>The case emphasizes the importance of considering dietary supplements as potential contributors to adverse health events, especially in patients with complex medical histories.</p>