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Background <p>Inflammatory myofibroblastic tumors are extremely rare in the neck of infants, and pathological diagnosis may be challenging. Kinase fusions play an important role in the biology of many inflammatory myofibroblastic tumors, becoming an effective diagnostic method.</p> Case presentation <p>In this report, we present the case of an East Asian (Han Chinese) patient with rare infant inflammatory myofibroblastoma. DNA-based but not RNA-based next-generation sequencing was used to identify its targetable <i>ROS1</i> fusions.</p> Conclusion <p>This case highlights the importance of simultaneously detecting DNA and RNA using next-generation sequencing in clinical practice.</p>

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An infant inflammatory myofibroblastoma with TFG-ROS1 fusion: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月9日

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  • Hui Jiang,
  • Junnan Jiang,
  • Baidong Feng,
  • Yaxian Yang,
  • Qi Li,
  • Bin Lian,
  • Xiao Ding,
  • Zhaodong Pan,
  • Mingjian Huang,
  • Zhaowen Pan,
  • Jian Huang

摘要

Background

Inflammatory myofibroblastic tumors are extremely rare in the neck of infants, and pathological diagnosis may be challenging. Kinase fusions play an important role in the biology of many inflammatory myofibroblastic tumors, becoming an effective diagnostic method.

Case presentation

In this report, we present the case of an East Asian (Han Chinese) patient with rare infant inflammatory myofibroblastoma. DNA-based but not RNA-based next-generation sequencing was used to identify its targetable ROS1 fusions.

Conclusion

This case highlights the importance of simultaneously detecting DNA and RNA using next-generation sequencing in clinical practice.