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Background <p>Neurosyphilis typically presents with nonspecific symptoms such as behavioral changes or cognitive impairment, rather than an initial stroke.</p> Case presentation <p>This case report describes a Black African man in his thirties who experienced sudden weakness on the left side of his body. Computed tomography suggested a nucleo-capsular ischemic lesion. However, given his young age and lack of traditional stroke risk factors, further investigations were pursued. Laboratory tests revealed positive results for syphilis in both blood and cerebrospinal fluid. Additional imaging (head and neck angiography) indicated intracranial vasculitis with widespread and acute ischemia in the right hemisphere. Treatment with ceftriaxone and aspirin was initiated. Through ongoing monitoring and care, the patient’s neurological condition improved.</p> Conclusion <p>The case underscores the critical need for prompt diagnosis and comprehensive assessment in patients experiencing stroke-like symptoms, especially in younger individuals. By recognizing neurosyphilis as a potential cause, healthcare providers can initiate timely treatment and improve patient outcomes.</p>

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Ischemic stroke as a presenting feature of neurosyphilis in an immunocompetent adult and attained complete recovery following treatment: a case report and review of the literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月14日

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  • Elsah Tegene Asefa,
  • Tamirat Godebo Woyimo,
  • Yosef Bekele Bonsa,
  • Addisalem Gebre Silase

摘要

Background

Neurosyphilis typically presents with nonspecific symptoms such as behavioral changes or cognitive impairment, rather than an initial stroke.

Case presentation

This case report describes a Black African man in his thirties who experienced sudden weakness on the left side of his body. Computed tomography suggested a nucleo-capsular ischemic lesion. However, given his young age and lack of traditional stroke risk factors, further investigations were pursued. Laboratory tests revealed positive results for syphilis in both blood and cerebrospinal fluid. Additional imaging (head and neck angiography) indicated intracranial vasculitis with widespread and acute ischemia in the right hemisphere. Treatment with ceftriaxone and aspirin was initiated. Through ongoing monitoring and care, the patient’s neurological condition improved.

Conclusion

The case underscores the critical need for prompt diagnosis and comprehensive assessment in patients experiencing stroke-like symptoms, especially in younger individuals. By recognizing neurosyphilis as a potential cause, healthcare providers can initiate timely treatment and improve patient outcomes.