Objectives To assess the potential of fast field echo resembling a CT using restricted echo-spacing (FRACTURE) sequence to enhance conventional MRI in detecting bone abnormalities of cervical spondylosis. Materials and methods 137 consecutive patients with cervical spondylosis who underwent clinically indicated paired CT and MRI within 2 weeks between January and June 2024. After routine MRI, the 3D-FRACTURE sequences were performed. Three radiologists independently evaluated the data during three sessions: (1) CT with consensus, (2) routine MRI, and (3) FRACTURE, with a 4-week interval between sessions. Assessments included osteophytes, bony foraminal stenosis, posterior longitudinal ligament ossification (OPLL), their anatomical location, and diagnostic confidence, using CT as the reference standard. Inter- and intra-reader reproducibility was assessed using multi-rater Fleiss κ and the intraclass correlation coefficient (ICC), respectively. The non-inferiority assessment compared routine MRI/FRACTURE and CT diagnoses using a relative reduction margin of 0.5. Results The study sample comprised 82 males and 55 females (age 56.9 ± 9.8 years). ICC indicated good to excellent inter-rater reliability for FRACTURE (osteophytes: ICC, 0.83–1.00; OPLL: ICC, 0.73–0.92; bony foraminal stenosis: ICC, 0.76–0.98), which was superior to conventional MRI (most ICC values < 0.7). The diagnostic confidence by FRACTURE sequences was significantly higher than by routine MRI (p < 0.001). Non-inferiority analysis demonstrated that FRACTURE and CT detection were similar for osteophyte, bony foraminal stenosis, and OPLL within a margin of 0.5. Conclusion The FRACTURE sequence demonstrated comparable performance to CT in bone abnormalities detection in cervical spondylosis, superior to the routine MRI protocol. Critical relevance statement The FRACTURE sequence addresses the limitations of conventional MRI in evaluating bone abnormalities, potentially minimizing radiation exposure and streamlining the diagnostic process for patients. Key Points <UnorderedList Mark="Bullet"> <ItemContent> MRI has advantages in the evaluation of cervical spondylosis, but is still insufficient in bone abnormalities evaluation. </ItemContent> <ItemContent> The FRACTURE sequence performed comparably to CT in bone abnormalities detection in cervical spondylosis. </ItemContent> <ItemContent> MRI with FRACTURE sequences may provide a non-ionizing method for assessing cervical spondylosis in some clinical settings. </ItemContent> </UnorderedList> Graphical Abstract

Added value of 3D fast-field-echo (FRACTURE) sequences for cervical spondylosis diagnosis: a prospective multi-reader non-inferiority study

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2025年6月3日

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Qizheng Wang,
Xiaoying Xing,
Zixian Zhang,
Xiaoxi Ji,
Shipei He,
Yuxin Yang,
Jiajia Xu,
Qiang Zhao,
Ning Lang

摘要

Objectives

To assess the potential of fast field echo resembling a CT using restricted echo-spacing (FRACTURE) sequence to enhance conventional MRI in detecting bone abnormalities of cervical spondylosis.

Materials and methods

137 consecutive patients with cervical spondylosis who underwent clinically indicated paired CT and MRI within 2 weeks between January and June 2024. After routine MRI, the 3D-FRACTURE sequences were performed. Three radiologists independently evaluated the data during three sessions: (1) CT with consensus, (2) routine MRI, and (3) FRACTURE, with a 4-week interval between sessions. Assessments included osteophytes, bony foraminal stenosis, posterior longitudinal ligament ossification (OPLL), their anatomical location, and diagnostic confidence, using CT as the reference standard. Inter- and intra-reader reproducibility was assessed using multi-rater Fleiss κ and the intraclass correlation coefficient (ICC), respectively. The non-inferiority assessment compared routine MRI/FRACTURE and CT diagnoses using a relative reduction margin of 0.5.

Results

The study sample comprised 82 males and 55 females (age 56.9 ± 9.8 years). ICC indicated good to excellent inter-rater reliability for FRACTURE (osteophytes: ICC, 0.83–1.00; OPLL: ICC, 0.73–0.92; bony foraminal stenosis: ICC, 0.76–0.98), which was superior to conventional MRI (most ICC values < 0.7). The diagnostic confidence by FRACTURE sequences was significantly higher than by routine MRI (p < 0.001). Non-inferiority analysis demonstrated that FRACTURE and CT detection were similar for osteophyte, bony foraminal stenosis, and OPLL within a margin of 0.5.

Conclusion

The FRACTURE sequence demonstrated comparable performance to CT in bone abnormalities detection in cervical spondylosis, superior to the routine MRI protocol.

Critical relevance statement

The FRACTURE sequence addresses the limitations of conventional MRI in evaluating bone abnormalities, potentially minimizing radiation exposure and streamlining the diagnostic process for patients.

Key Points

MRI has advantages in the evaluation of cervical spondylosis, but is still insufficient in bone abnormalities evaluation.

The FRACTURE sequence performed comparably to CT in bone abnormalities detection in cervical spondylosis.

MRI with FRACTURE sequences may provide a non-ionizing method for assessing cervical spondylosis in some clinical settings.

Graphical Abstract