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<p>In this letter, we report that ragweed-allergic participants with nasal <i>Staphylococcus aureus</i> carriage (n = 7) exhibited significantly smaller reductions in Peak Nasal Inspiratory Flow from baseline at 3&#xa0;h (<i>P</i> = 0.013) and 5&#xa0;h (<i>P</i> = 0.008) post–nasal allergen challenge compared to non-carriers (n = 12). There was no significant difference between carriers and non-carriers in the initial response within the first three hours following the challenge (all <i>P</i> &gt; 0.05). Carriers also reported significantly lower Total Nasal Symptom Scores (<i>P</i> = 0.015) and Total Rhinoconjunctivitis Symptom Scores (<i>P</i> = 0.021) at 48&#xa0;h. These findings suggest that <i>S. aureus</i> carriage does not exacerbate allergic responses and may instead be associated with more rapid symptom resolution.</p>

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Staphylococcus aureus nasal carriage is associated with faster symptom resolution following nasal allergen challenge in ragweed-allergic participants: a subset of the Allergic Rhinitis Microbiome Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月19日

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  • Sophia Linton,
  • Lubnaa Hossenbaccus,
  • Abigail Davis,
  • Jenny Thiele,
  • Sarah Garvey,
  • Hannah Botting,
  • Lisa Steacy,
  • Prameet M. Sheth,
  • Anne K. Ellis

摘要

In this letter, we report that ragweed-allergic participants with nasal Staphylococcus aureus carriage (n = 7) exhibited significantly smaller reductions in Peak Nasal Inspiratory Flow from baseline at 3 h (P = 0.013) and 5 h (P = 0.008) post–nasal allergen challenge compared to non-carriers (n = 12). There was no significant difference between carriers and non-carriers in the initial response within the first three hours following the challenge (all P > 0.05). Carriers also reported significantly lower Total Nasal Symptom Scores (P = 0.015) and Total Rhinoconjunctivitis Symptom Scores (P = 0.021) at 48 h. These findings suggest that S. aureus carriage does not exacerbate allergic responses and may instead be associated with more rapid symptom resolution.