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Objectives <p>Apolipoprotein E (APOE) status was determined by directly genotyping the genetic variants, rs7412 and rs429358 in the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA), harnessing blood-derived DNA. This data was generated on a subset of participants (<i>n</i> = 2947) within the NICOLA cohort.</p> Data description <p>The NICOLA study recruited approximately 8500 people from across Northern Ireland, with individuals recruited representative of the Northern Ireland population. At baseline, 45% of participants were male and 55% were female. Adults were recruited over the age of 50, with approximately 50% of participants aged between 50 and 65, and 10% of participants over the age of 80. APOE status was determined for 2947 individuals (47.6% male). The APOE protein has three major isoforms (ɛ2, ɛ3, and ɛ4), determined from the direct genotyping of two single nucleotide polymorphisms (SNPs) SNPs, rs7412 and rs429358.</p>

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Apolipoprotein E (APOE) genotyping in the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月23日

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  • Claire Hill,
  • Claire Potter,
  • Laura Smyth,
  • Jill Kilner,
  • Katie Quinn,
  • Angela Scott,
  • Charlotte Neville,
  • Frank Kee,
  • Bernadette McGuinness,
  • Amy Jayne McKnight

摘要

Objectives

Apolipoprotein E (APOE) status was determined by directly genotyping the genetic variants, rs7412 and rs429358 in the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA), harnessing blood-derived DNA. This data was generated on a subset of participants (n = 2947) within the NICOLA cohort.

Data description

The NICOLA study recruited approximately 8500 people from across Northern Ireland, with individuals recruited representative of the Northern Ireland population. At baseline, 45% of participants were male and 55% were female. Adults were recruited over the age of 50, with approximately 50% of participants aged between 50 and 65, and 10% of participants over the age of 80. APOE status was determined for 2947 individuals (47.6% male). The APOE protein has three major isoforms (ɛ2, ɛ3, and ɛ4), determined from the direct genotyping of two single nucleotide polymorphisms (SNPs) SNPs, rs7412 and rs429358.