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Objective <p>This study aimed to examine the associations of weight loss, low serum albumin levels, and their combination with 2-year mortality risk in older adults receiving home medical care.</p> Results <p>Participants from the Osaka Home Care Registry Study aged 65 or older were classified into two groups: low and high baseline serum albumin levels, and stratified into those with 5% weight loss and weight maintenance after 1 year. Low serum albumin and weight loss were present in 21.8% and 20.8% of participants, respectively. In multivariable Cox proportional hazards analysis, combinations involving low serum albumin were significantly associated with mortality. Participants with weight maintenance and low serum albumin (HR = 6.89, 95%CI = 2.06–23.02) and those with weight loss and low serum albumin (HR = 19.06, 95%CI = 4.42–82.14) had a higher mortality risk, whereas weight loss alone was not significant. These findings suggest that evaluating serum albumin together with weight change may help identify high-risk individuals in home medical care.</p>

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Associations of weight loss, low serum albumin, and their combination with mortality risk in older adults receiving home medical care

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月20日

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  • Tomoko Yano,
  • Naoko Murakami,
  • Yuka Fukata,
  • Chika Nakamura,
  • Chihiro Anzai,
  • Yumiko Nako,
  • Eriko Koujiya,
  • Toshinori Nakamura,
  • Atsushi Hirotani,
  • Toshio Fukuda,
  • Michio Tamatani,
  • Yoshinari Okuda,
  • Masashi Ikushima,
  • Yoshichika Baba,
  • Masahiro Nagano,
  • Yukio Nakamura,
  • Taizo Wada,
  • Yuya Akagi,
  • Kayo Godai,
  • Michiko Kido,
  • Mai Kabayama,
  • Hiromi Rakugi,
  • Kei Kamide

摘要

Objective

This study aimed to examine the associations of weight loss, low serum albumin levels, and their combination with 2-year mortality risk in older adults receiving home medical care.

Results

Participants from the Osaka Home Care Registry Study aged 65 or older were classified into two groups: low and high baseline serum albumin levels, and stratified into those with 5% weight loss and weight maintenance after 1 year. Low serum albumin and weight loss were present in 21.8% and 20.8% of participants, respectively. In multivariable Cox proportional hazards analysis, combinations involving low serum albumin were significantly associated with mortality. Participants with weight maintenance and low serum albumin (HR = 6.89, 95%CI = 2.06–23.02) and those with weight loss and low serum albumin (HR = 19.06, 95%CI = 4.42–82.14) had a higher mortality risk, whereas weight loss alone was not significant. These findings suggest that evaluating serum albumin together with weight change may help identify high-risk individuals in home medical care.