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Objective <p>Metabolic syndrome (MetS), beyond its well-established link to the rising tide of chronic conditions, casts a significant shadow on individual’s daily well-being, diminishing their Health-related quality of life (HRQOL). This study examines the association between MetS and HRQOL with a focus on gender differences among a cohort of healthcare workers.</p> Results <p>In this study, the prevalence of MetS was 9.3%, with a higher prevalence in men (10.3%) than in women (8.5%). Women with MetS reported significantly lower overall HRQOL scores compared to women without MetS (β = -1.89, <i>p</i>&lt; 0.001), while no such association was found in men (β = 0.05, <i>p</i> = 0.922). Additionally, a significant gender-dependent interaction was observed, with a stronger association between MetS and lower physical HRQOL scores in women than in men (β = -3.17 vs. β = -2.17). Findings highlight a gender-specific pattern in the association between MetS and reduced HRQOL, emphasizing the need for targeted interventions.</p>

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Metabolic syndrome and health-related quality of life: unraveling the role of gender (A SUMS employees cohort-based study)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月5日

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  • Fatemeh Rezaei chegini,
  • Mozhgan Seif,
  • Mohebat Vali,
  • Seyed Jalil Masoumi,
  • Haleh Ghaem

摘要

Objective

Metabolic syndrome (MetS), beyond its well-established link to the rising tide of chronic conditions, casts a significant shadow on individual’s daily well-being, diminishing their Health-related quality of life (HRQOL). This study examines the association between MetS and HRQOL with a focus on gender differences among a cohort of healthcare workers.

Results

In this study, the prevalence of MetS was 9.3%, with a higher prevalence in men (10.3%) than in women (8.5%). Women with MetS reported significantly lower overall HRQOL scores compared to women without MetS (β = -1.89, p< 0.001), while no such association was found in men (β = 0.05, p = 0.922). Additionally, a significant gender-dependent interaction was observed, with a stronger association between MetS and lower physical HRQOL scores in women than in men (β = -3.17 vs. β = -2.17). Findings highlight a gender-specific pattern in the association between MetS and reduced HRQOL, emphasizing the need for targeted interventions.