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Objectives <p>To evaluate lipid accumulation product (LAP) as a predictor of all-cause mortality in type 2 diabetes mellitus (T2DM) patients with heart failure with reduced ejection fraction (HFrEF).</p> Results <p>Among 926 T2DM-HFrEF patients followed for 29.9&#xa0;months (median), high LAP independently predicted increased mortality risk (adjusted HR: 3.102, 95% CI 2.142–4.491; P &lt; 0.001). LAP exhibited a nonlinear association with mortality (<i>P</i> for Nonlinear &lt; 0.001) and demonstrated moderate predictive accuracy (AUC = 0.643, 95% CI 0.602–0.684).</p>

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Prognostic value of lipid accumulation product in patients with type 2 diabetes mellitus and heart failure with reduced ejection fraction: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月31日

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  • Hao Wang,
  • Xiaoli Ma,
  • Dan Zhang,
  • Shunmin Liu,
  • Xiang Ma,
  • Xiang Zhao

摘要

Objectives

To evaluate lipid accumulation product (LAP) as a predictor of all-cause mortality in type 2 diabetes mellitus (T2DM) patients with heart failure with reduced ejection fraction (HFrEF).

Results

Among 926 T2DM-HFrEF patients followed for 29.9 months (median), high LAP independently predicted increased mortality risk (adjusted HR: 3.102, 95% CI 2.142–4.491; P < 0.001). LAP exhibited a nonlinear association with mortality (P for Nonlinear < 0.001) and demonstrated moderate predictive accuracy (AUC = 0.643, 95% CI 0.602–0.684).