Scholarlink

Objective <p>Candidiasis, an opportunistic infection that is prevalent in HIV-positive children and adults, is caused by various <i>Candida</i> species, <i>Candida albicans</i> along with certain non-albicans <i>Candida</i> species. The prevalence of these species varies across age groups due to multiple factors. Identification of these species becomes necessary as any antifungal therapy requires species-specific targeting to manage candidiasis effectively. With this background, the present study aimed to evaluate the prevalence and speciation of <i>Candida</i> in HIV-positive children (<i>n</i> = 30) and adults (<i>n</i> = 40) and to compare these findings with those in healthy individuals. Ten mL saliva was collected from HIV-positive and HIV-negative (healthy) patients and cultured on CHROMAgar™.</p> Results <p>The proportion and quantity of candidal colonization was higher in HIV-positive children (93.30%) as compared to adults (67.50%). An increased profile of <i>Nakaseomyces glabrata (</i>previously <i>Candida glabrata)</i> was seen in children while the adults showed increase in colonization of <i>C. tropicalis.</i> The shift in profiles of species from <i>Candida albicans</i> to ‘<i>non-albicans’ Candida</i> species is of clinical relevance as it directly impacts on the antimicrobial efficacy of chosen anti-fungal agents.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Candidal speciation and carriage in oral cavity of HIV-positive children/adults and healthy individuals in the South Canara district of India: a comparative study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月27日

查看全文
  • Sneha KS,
  • Srikant Natarajan,
  • Karen Boaz,
  • Shrikala Baliga,
  • John Ramapuram,
  • Monica Charlotte Solomon,
  • Nidhi Manaktala,
  • Nunna Sai Chitra

摘要

Objective

Candidiasis, an opportunistic infection that is prevalent in HIV-positive children and adults, is caused by various Candida species, Candida albicans along with certain non-albicans Candida species. The prevalence of these species varies across age groups due to multiple factors. Identification of these species becomes necessary as any antifungal therapy requires species-specific targeting to manage candidiasis effectively. With this background, the present study aimed to evaluate the prevalence and speciation of Candida in HIV-positive children (n = 30) and adults (n = 40) and to compare these findings with those in healthy individuals. Ten mL saliva was collected from HIV-positive and HIV-negative (healthy) patients and cultured on CHROMAgar™.

Results

The proportion and quantity of candidal colonization was higher in HIV-positive children (93.30%) as compared to adults (67.50%). An increased profile of Nakaseomyces glabrata (previously Candida glabrata) was seen in children while the adults showed increase in colonization of C. tropicalis. The shift in profiles of species from Candida albicans to ‘non-albicans’ Candida species is of clinical relevance as it directly impacts on the antimicrobial efficacy of chosen anti-fungal agents.