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Objective <p>The <i>CAPN10</i> gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic disorders, mainly obesity. This study aimed to investigate the association between the <i>CAPN10</i> Indel-19 variant and some clinical parameters in a Mexican population sample. We recruited 426 apparently healthy individuals over 30 years of age. We obtained anthropometric data, arterial pressure, fasting biochemical parameters, and genotyping for <i>CAPN10</i> Indel-19.</p> Results <p>The frequency of overweight and obesity was 82.9%, hypertension 8%, hypercholesterolemia 14.8%, hypertriglyceridemia 31.9%, impaired plasma glucose 23.9%, and diabetes 4.7%. The genotype frequencies were 13.1%, 47.9%, and 39% for <i>del/del</i>, <i>del/ins</i>, and <i>ins/ins</i>, respectively; the allele frequencies were 37.1% for the <i>del</i> allele and 62.9% for the <i>ins</i> allele. The analysis of the continuous parameters according to the genotypes showed no significant differences. However, when these parameters were dichotomized (reference group <i>versus</i> high-level group), the <i>ins</i> allele was associated with a protective effect against high arterial pressure (prehypertension and hypertension). It is unclear whether the <i>CAPN10</i> Indel-19 variant increases the risk of chronic diseases, so further studies are needed to confirm or refute this issue.</p>

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Lack of association of the calpain-10 Indel-19 variant with chronic diseases in a Mexican population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月31日

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  • Juan Pablo Meza-Espinoza,
  • Juan de Dios Zavala-Rubio,
  • Evelia Leal-Ugarte,
  • Verónica Judith Picos-Cárdenas,
  • José Alfredo Contreras-Gutiérrez,
  • Jesús Madueña-Molina,
  • Josué Camberos-Barraza,
  • Salvador Cervín-Serrano,
  • María Lourdes Varela Germán

摘要

Objective

The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic disorders, mainly obesity. This study aimed to investigate the association between the CAPN10 Indel-19 variant and some clinical parameters in a Mexican population sample. We recruited 426 apparently healthy individuals over 30 years of age. We obtained anthropometric data, arterial pressure, fasting biochemical parameters, and genotyping for CAPN10 Indel-19.

Results

The frequency of overweight and obesity was 82.9%, hypertension 8%, hypercholesterolemia 14.8%, hypertriglyceridemia 31.9%, impaired plasma glucose 23.9%, and diabetes 4.7%. The genotype frequencies were 13.1%, 47.9%, and 39% for del/del, del/ins, and ins/ins, respectively; the allele frequencies were 37.1% for the del allele and 62.9% for the ins allele. The analysis of the continuous parameters according to the genotypes showed no significant differences. However, when these parameters were dichotomized (reference group versus high-level group), the ins allele was associated with a protective effect against high arterial pressure (prehypertension and hypertension). It is unclear whether the CAPN10 Indel-19 variant increases the risk of chronic diseases, so further studies are needed to confirm or refute this issue.