Background <p>The recent global pandemic posed extraordinary challenges for healthcare systems. Frontline healthcare workers required focused, immediate, practical, evidence-based instruction on optimal patient care modalities as knowledge evolved around disease management.</p> Objective <p>This course was designed to provide knowledge to protect healthcare workers; combat disease spread; and improve patient outcomes.</p> Methods <p>A team of global healthcare workers responded by rapidly creating a competency-based online course. To promote transcultural applicability, the course was developed by an international team of more than 45 educators from over 20 countries. Course delivery included a built-in language translation tool, routine updates, and several innovative course design elements. User feedback was collected to determine efficacy of course content, structure, unique delivery elements, and delivery options.</p> Results <p>An initial population of online learners (<i>n</i> = 147) living in 23 different countries and representing 22 languages completed the course and participated in post-course surveys. An additional population of learners (<i>n</i> = 505) attended an in-person offering of course materials. Course participants gave positive feedback and several requested additional courses in similar formats.</p> Conclusion <p>Global open access education courses may provide needed resources to empower healthcare professionals during health crises. Responsive course design can accommodate diverse learner resources and transcultural applicability.</p>