Background <p>This study aimed to investigate the effectiveness of a single session of high-pressure intermittent pneumatic compression (IPC) on post-match recovery in international level youth soccer players, using neuromuscular, biochemical, and perceptual markers.</p> Methods <p>Forty-two observations (across 6 matches) of 23 elite U19 soccer players (age: 17.45 ± 0.72 years; height: 1.82 ± 0.06&#xa0;m; body mass: 74.95 ± 6.45&#xa0;kg) participated in this randomized, placebo-controlled trial. Following competitive matches, participants were assigned to receive either 30&#xa0;min of high-pressure IPC (200 mmHg) or a placebo intervention (hydrant cream). Recovery status was assessed pre-match, and at 30&#xa0;min, 24- and 48-hours post-match using countermovement jump height, low-frequency fatigue of the knee extensors (Myocene^®), creatine kinase (CK) concentrations, and self-reported fatigue and soreness. Linear mixed models were used to examine the effects of time, group, and time x group interaction. Covariates such as perceived exertion, GPS metrics, and sleep metrics were included when appropriate.</p> Results <p>No significant time x group interactions were found for any of the variables under analysis (<i>p</i> = 0.089 to 0.834). Significant main effects of time were detected in CK, perceived fatigue and soreness (<i>p</i> &lt; 0.001), confirming match-induced fatigue, but without group differences. Exploratory analyses revealed that internal and external load, as well as total sleep time influenced recovery markers, particularly CK and perceptual responses.</p> Conclusion <p>A single session of high-pressure IPC does not seem to enhance post-match recovery in elite youth soccer players compared to a placebo, on neuromuscular, biochemical, and subjective markers.</p> Trial registration <p>ClinicalTrials.gov code NCT06636942 (date of registration: 02/10/2024).</p>