Scholarlink

Aim <p><i>Blastocystis</i> spp. is a common intestinal protozoan with controversial pathogenicity. It is frequently associated with gastrointestinal (GIT) disturbances and is particularly prevalent among immunocompromised individuals. This study aimed to assess the prevalence of <i>Blastocystis</i> spp. infection and its association with immunological and hematological parameters among chronic leukemic patients.</p> Methods <p>Stool and blood samples were collected from 100 chronic leukemic patients. Microscopic examination and a coproantigen assay were performed for the detection of <i>Blastocystis</i> spp., along with assessment of anti-<i>Blastocystis</i> fecal IgA and serum IgG antibodies. CD4 T cells and the serum level of IL-8 were also measured.</p> Results <p>The overall <i>Blastocystis</i> spp. infection rate was 60%, determined through combined microscopy and/or coproantigen detection. Among infected patients, anti-<i>Blastocystis</i> IgA was positive in only three patients and IgG in 18 patients, with no statistically significant association between <i>Blastocystis</i> spp. infection and detection of antibodies. Infection was significantly associated with elevated IL-8 levels and WBC count. There was no statistically significant association between the presence of gastrointestinal symptoms and the levels of anti-<i>Blastocystis</i> IgG or IgA, IL-8, or CD4 count in <i>Blastocystis</i> spp.-infected patients.</p> Conclusion <p>Our study reveals a high prevalence of <i>Blastocystis</i> spp. infection among chronic leukemic patients and identifies a significant association between infection and elevated IL-8 levels.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Assessment of immunological and hematological parameters in Blastocystis species-infected chronic leukemic patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月11日

查看全文
  • Heba Elhadad,
  • Bassam Mohamed Abdel-Fattah,
  • Sally A. M. Saleh,
  • Moustafa Abo El-Hoda,
  • Hend El-Taweel

摘要

Aim

Blastocystis spp. is a common intestinal protozoan with controversial pathogenicity. It is frequently associated with gastrointestinal (GIT) disturbances and is particularly prevalent among immunocompromised individuals. This study aimed to assess the prevalence of Blastocystis spp. infection and its association with immunological and hematological parameters among chronic leukemic patients.

Methods

Stool and blood samples were collected from 100 chronic leukemic patients. Microscopic examination and a coproantigen assay were performed for the detection of Blastocystis spp., along with assessment of anti-Blastocystis fecal IgA and serum IgG antibodies. CD4 T cells and the serum level of IL-8 were also measured.

Results

The overall Blastocystis spp. infection rate was 60%, determined through combined microscopy and/or coproantigen detection. Among infected patients, anti-Blastocystis IgA was positive in only three patients and IgG in 18 patients, with no statistically significant association between Blastocystis spp. infection and detection of antibodies. Infection was significantly associated with elevated IL-8 levels and WBC count. There was no statistically significant association between the presence of gastrointestinal symptoms and the levels of anti-Blastocystis IgG or IgA, IL-8, or CD4 count in Blastocystis spp.-infected patients.

Conclusion

Our study reveals a high prevalence of Blastocystis spp. infection among chronic leukemic patients and identifies a significant association between infection and elevated IL-8 levels.