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Objective <p>Obesity-related dyslipidemia remains a significant health challenge, contributing to increased cardiovascular risk. Hydrogen-rich water (HRW) has been proposed as a potential adjunctive intervention due to its antioxidant and anti-inflammatory properties. This systematic review and meta-analysis aimed to evaluate the effects of HRW on lipid profiles in adults with overweight or obesity.</p> Methods <p>We searched Scopus, PubMed, Web of Science, and Embase for randomized controlled trials (RCTs) published up to November 2025 that compared HRW with placebo or standard water in adults with mean body mass index (BMI) ≥ 25&#xa0;kg/m². Random-effects meta-analyses were performed to estimate pooled weighted mean differences (WMDs) and 95% confidence intervals (CIs).</p> Results <p>Twelve articles comprising 13 RCTs (<i>n</i> = 757 participants) were included. HRW significantly reduced total cholesterol (TC) (WMD: − 6.71&#xa0;mg/dL; 95% CI: − 10.38 to − 3.04; <i>P</i> &lt; 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: − 3.21&#xa0;mg/dL; 95% CI: − 6.31 to − 0.10; <i>P</i> = 0.043). A small reduction in high-density lipoprotein cholesterol (HDL-C) was observed (WMD: − 1.16&#xa0;mg/dL; 95% CI: − 1.92 to − 0.40; <i>P</i> = 0.003). Triglycerides showed no significant change (WMD: − 4.21&#xa0;mg/dL; 95% CI: − 17.75 to 9.32; <i>P</i> = 0.54). Most trials enrolled overweight or obese adults with cardiometabolic comorbidities. Subgroup analyses were underpowered and considered hypothesis-generating.</p> Conclusion <p>HRW supplementation in overweight or obese adults produces small, statistically detectable but clinically modest reductions in TC and LDL-C, with minimal effects on TG and HDL-C. These effects are below thresholds considered meaningful for cardiovascular risk reduction and should not justify routine use of HRW as a lipid-lowering therapy outside of research settings and these findings primarily apply to adults with preexisting metabolic conditions and should not be generalized to all overweight/obese individuals. Any potential role remains limited to an investigational adjunct, and further adequately powered, longer-term RCTs are needed before HRW can be considered in dyslipidemia management.</p>

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The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月26日

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  • Honghui Ye,
  • Jinyong Fang,
  • Mohammad Safargar,
  • Hadi Fareed,
  • Kousalya Prabahar,
  • Pei Jin

摘要

Objective

Obesity-related dyslipidemia remains a significant health challenge, contributing to increased cardiovascular risk. Hydrogen-rich water (HRW) has been proposed as a potential adjunctive intervention due to its antioxidant and anti-inflammatory properties. This systematic review and meta-analysis aimed to evaluate the effects of HRW on lipid profiles in adults with overweight or obesity.

Methods

We searched Scopus, PubMed, Web of Science, and Embase for randomized controlled trials (RCTs) published up to November 2025 that compared HRW with placebo or standard water in adults with mean body mass index (BMI) ≥ 25 kg/m². Random-effects meta-analyses were performed to estimate pooled weighted mean differences (WMDs) and 95% confidence intervals (CIs).

Results

Twelve articles comprising 13 RCTs (n = 757 participants) were included. HRW significantly reduced total cholesterol (TC) (WMD: − 6.71 mg/dL; 95% CI: − 10.38 to − 3.04; P < 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: − 3.21 mg/dL; 95% CI: − 6.31 to − 0.10; P = 0.043). A small reduction in high-density lipoprotein cholesterol (HDL-C) was observed (WMD: − 1.16 mg/dL; 95% CI: − 1.92 to − 0.40; P = 0.003). Triglycerides showed no significant change (WMD: − 4.21 mg/dL; 95% CI: − 17.75 to 9.32; P = 0.54). Most trials enrolled overweight or obese adults with cardiometabolic comorbidities. Subgroup analyses were underpowered and considered hypothesis-generating.

Conclusion

HRW supplementation in overweight or obese adults produces small, statistically detectable but clinically modest reductions in TC and LDL-C, with minimal effects on TG and HDL-C. These effects are below thresholds considered meaningful for cardiovascular risk reduction and should not justify routine use of HRW as a lipid-lowering therapy outside of research settings and these findings primarily apply to adults with preexisting metabolic conditions and should not be generalized to all overweight/obese individuals. Any potential role remains limited to an investigational adjunct, and further adequately powered, longer-term RCTs are needed before HRW can be considered in dyslipidemia management.