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Objective <p>The present study aims to investigate the association of low body mass index (BMI &lt; 22&#xa0;kg/m<sup>2</sup>) and core lipid parameters on all-cause mortality among older adults with type 2 diabetes mellitus (T2DM), and to assess the mediating roles of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).</p> Methods <p>Data were analyzed from 372,559 T2DM participants aged ≥ 60&#xa0;years, obtained from the Shanghai Center for Disease Control and Prevention (SCDC) diabetes management cohort, stratified by BMI &lt; 22&#xa0;kg/m<sup>2</sup>. Associations between low BMI and lipid parameters were examined using linear regression, associations of low BMI and lipid parameters with mortality risk were assessed via Cox regression. Restricted cubic spline (RCS) models were used to evaluate nonlinear trends, and Bayesian mediation models quantified the mediating effects.</p> Results <p>The low BMI group had a significantly higher risk of all-cause mortality compared to the non-low BMI group (HR = 1.10, 95% CI: 1.06 ~ 1.13). Among the lipid parameters, TC, HDL-C, and LDL-C were nonlinearly associated with mortality risk (U-shaped for TC and LDL-C, L-shaped for HDL-C), with optimal thresholds identified at 5.03&#xa0;mmol/L, 0.98&#xa0;mmol/L, and 3.39&#xa0;mmol/L, respectively. Mediation analysis demonstrated significant negative mediation for TC (proportion mediated, PE = –16.68%), HDL-C (PE = –111.99%), and LDL-C (PE = –4.12%), with HDL-C showing the strongest masking effect (βACME = 1.44, 95% CI: 1.33 ~ 1.56).</p> Conclusion <p>Low BMI is independently associated with an increased risk of mortality in T2DM older adults. Cholesterol parameters, particularly HDL-C, may explain part of this association through negative mediation. These findings suggest the need for clinical attention to lipid metabolic disturbances among underweight older adults.</p>

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Low BMI predicts mortality in T2DM older adults: cholesterol parameters demonstrate negative mediation

  • 期刊论文

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  • 发表日期：

    2026年3月3日

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  • Hongfei Mo,
  • Qinping Yang,
  • Yining Wang,
  • Qinghua Yan,
  • Shuyue Sun,
  • Huiting Yu,
  • Yan Shi,
  • Fan Wang,
  • Minna Cheng

摘要

Objective

The present study aims to investigate the association of low body mass index (BMI < 22 kg/m2) and core lipid parameters on all-cause mortality among older adults with type 2 diabetes mellitus (T2DM), and to assess the mediating roles of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).

Methods

Data were analyzed from 372,559 T2DM participants aged ≥ 60 years, obtained from the Shanghai Center for Disease Control and Prevention (SCDC) diabetes management cohort, stratified by BMI < 22 kg/m2. Associations between low BMI and lipid parameters were examined using linear regression, associations of low BMI and lipid parameters with mortality risk were assessed via Cox regression. Restricted cubic spline (RCS) models were used to evaluate nonlinear trends, and Bayesian mediation models quantified the mediating effects.

Results

The low BMI group had a significantly higher risk of all-cause mortality compared to the non-low BMI group (HR = 1.10, 95% CI: 1.06 ~ 1.13). Among the lipid parameters, TC, HDL-C, and LDL-C were nonlinearly associated with mortality risk (U-shaped for TC and LDL-C, L-shaped for HDL-C), with optimal thresholds identified at 5.03 mmol/L, 0.98 mmol/L, and 3.39 mmol/L, respectively. Mediation analysis demonstrated significant negative mediation for TC (proportion mediated, PE = –16.68%), HDL-C (PE = –111.99%), and LDL-C (PE = –4.12%), with HDL-C showing the strongest masking effect (βACME = 1.44, 95% CI: 1.33 ~ 1.56).

Conclusion

Low BMI is independently associated with an increased risk of mortality in T2DM older adults. Cholesterol parameters, particularly HDL-C, may explain part of this association through negative mediation. These findings suggest the need for clinical attention to lipid metabolic disturbances among underweight older adults.