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Objectives <p>To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality.</p> Methods <p>ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model.</p> Results <p>A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; <i>p</i>&lt;0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;<i>p</i>=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death.</p> Conclusions <p>The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.</p>

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Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry

  • 期刊论文

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  • 发表日期：

    2025年1月7日

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  • Juan Molina-Collada,
  • Marta Domínguez-Álvaro,
  • Rafael B. Melero-González,
  • Eugenio de Miguel,
  • Maite Silva-Díaz,
  • Jesús Alejandro Valero Jaimes,
  • Ismael González,
  • Julio Sánchez Martín,
  • Javier Narváez,
  • Joan Calvet,
  • Ivette Casafont-Solé,
  • Jose A Román Ivorra,
  • Selene Labrada Arrabal,
  • Margarida Vasques Rocha,
  • Carlota L Iñiguez,
  • María Sagrario Bustabad Reyes,
  • Cristina Campos Fernández,
  • María Alcalde Villar,
  • Antonio Juan Mas,
  • Ricardo Blanco,
  • Clara Moriano Morales,
  • Elvira Díez Álvarez,
  • Trinidad Pérez Sandoval,
  • Vicente Aldasoro Cáceres,
  • Javier Mendizábal Mateos,
  • María Concepción Fito Manteca,
  • Natividad del Val del Amo,
  • Loreto Horcada Rubio,
  • Inmaculada Paniagua Zudaire,
  • Laura Garrido Courel,
  • Ricardo Gutiérrez Polo,
  • Juliana Restrepo Vélez,
  • Eduardo Loza Cortina,
  • Patricia Carreira,
  • Tomás Almorza,
  • Lydia Abasolo Alcázar,
  • Leticia Léon Mateos,
  • Luis Rodríguez Rodríguez,
  • Judit Font Urgelles,
  • Pia Mercedes Lois Bermejo,
  • Tarek Salman Monte,
  • Anne Riveros Frutos,
  • Susana Holgado Pérez,
  • Jordi Camins,
  • Clara Molina Almela,
  • Amalia Rueda Cid,
  • Javier Calvo Catalá,
  • Iñigo Hernández Rodríguez,
  • Francisco Maceiras,
  • Nair Pérez,
  • Ceferino Barbazán,
  • Jose María Pego,
  • Irena Altabás,
  • John Guzman,
  • Paula Valentina Estrada Alarcón,
  • Vanessa Andrea Navarro Angeles,
  • Patricia Moya Alvarado,
  • Hector Corominas,
  • Iván Castellví,
  • Berta Magallares,
  • Ana Milena Millán,
  • Ana F. Cruz Valenciano,
  • Félix Cabero del Pozo,
  • Ana Belén Rodríguez Cambrón,
  • Cristina Macia Villa,
  • Eva Álvarez de Andrés,
  • Inmaculada Ros Vilamajó,
  • Monica Ibáñez Barcelo,
  • Elide Toniolo,
  • Ana Paula Cacheda,
  • María García González,
  • Alicia García Dorta,
  • Vanesa Hernández Hernández,
  • Jaime Calvo Allen,
  • Elisa Fernandez-Fernandez,
  • Irene Monjo-Henry,
  • Santos Castañeda Sanz,
  • Mirem Uriarte-Ecenarro,
  • Cristina Valero Martínez,
  • Esther F. Vicente Rabaneda,
  • Carlos García Porrúa,
  • Noelia Álvarez Rivas,
  • Tomás Ramón Vázquez Rodríguez,
  • Jose Alberto Miranda Filloy,
  • Amalia Sánchez-Andrade Fernández,
  • Miguel Ángel González-Gay,
  • Carlos Galisteo Lencastre Da Veiga,
  • María Jesús García Villanueva,
  • Carmen Larena Grijalba,
  • Marina Tortosa Cabañas,
  • Patricia Morán Álvarez,
  • Marta Serrano Warleta,
  • Aliuska Palomeque Vargas,
  • Noemí Garrido,
  • Alberto Ruíz Roman,
  • Clara Aguilera Cros,
  • Alejandro Muñoz Jimenez,
  • Francisco Ortiz Sanjuán,
  • Carmen Riesco Bárcena,
  • Anderson Huaylla,
  • Eva Galíndez Agirregoikoa,
  • Itziar Calvo Zorrilla,
  • Judit Lluch,
  • Joaquín María Belzunegui,
  • Luis López Domínguez,
  • Cesar Antonio Egues Dubuc,
  • Lucia Silva Fernández

摘要

Objectives

To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality.

Methods

ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model.

Results

A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death.

Conclusions

The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.