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Background <p>Fleas and ticks can be found globally and are of both veterinary and human health concern due to their ability to transmit various vector-borne diseases. Heavy flea and tick infestations can result in significant blood loss, while flea infestations can result in intense pruritus. The use of safe and effective ectoparasiticides in veterinary medicine is a crucial part of protecting both pets and humans from infestations and transmission of vector-borne diseases.</p> Methods <p>The efficacy of a novel endectocide, Credelio Quattro, containing lotilaner, moxidectin, praziquantel, and pyrantel, was evaluated in four masked studies: one against <i>Ctenocephalides felis</i> and three against the dose-limiting tick <i>Rhipicephalus sanguineus</i>. Dogs were orally administered placebo, Credelio Quattro™, lotilaner only (Credelio™, Study 2), or pyrantel only (Study 2) in a fed state on Day 0. Experimental infestations with <i>C. felis</i> were conducted on Days −1, 6, 13, 20, 29, and 35 with 100 adult fleas. Fleas were removed and categorized as either live or dead 24&#xa0;h post-treatment and 24&#xa0;h post-infestation thereafter. Experimental infestations with <i>R. sanguineus</i> were conducted on Days −2, 5, 12, 19, and 30 with 50 adult ticks. Ticks were removed and categorized as attached or unattached and then live or dead 48&#xa0;h post-treatment and 48&#xa0;h post-infestation thereafter.</p> Results <p>Credelio Quattro demonstrated 100% (<i>P</i> &lt; 0.0001) efficacy against <i>C. felis</i>, with no live fleas recovered at time points evaluated through 36&#xa0;days post-treatment. Additionally, Credelio Quattro demonstrated 97.1–100% (<i>P</i> &lt; 0.0001) efficacy through Day 30 against the established dose-limiting tick species, <i>R. sanguineus</i>. In Study 2, pyrantel demonstrated ≤ 46.6% (<i>P</i> ≥ 0.0601) efficacy while lotilaner provided ≥ 99.6% (<i>P</i> ≤ 0.0007) efficacy, confirming lotilaner as the acaricidal active ingredient in Credelio Quattro. Adverse events were reported in both treatment groups, including dermatitis, alopecia, lameness, and a chest wound. One dog in a Credelio Quattro treatment group experienced vomiting and bloody diarrhea that was considered possibly treatment-related.</p> Conclusions <p>These studies confirm the safety and effectiveness of a single dose of Credelio Quattro for the treatment and control of <i>C. felis</i> and <i>R. sanguineus</i> infestations on dogs for 1&#xa0;month.</p> Graphical Abstract <p></p>

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Efficacy of Credelio Quattro™ chewable tablets containing lotilaner, moxidectin, pyrantel, and praziquantel against Ctenocephalides felis and Rhipicephalus sanguineus infestations on dogs

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月27日

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  • Lisa Young,
  • Xinshuo Wang,
  • Scott Wiseman,
  • William R. Everett,
  • Riaan Maree,
  • Utami R. DiCosty,
  • Carin Rautenbach,
  • Molly D. Savadelis

摘要

Background

Fleas and ticks can be found globally and are of both veterinary and human health concern due to their ability to transmit various vector-borne diseases. Heavy flea and tick infestations can result in significant blood loss, while flea infestations can result in intense pruritus. The use of safe and effective ectoparasiticides in veterinary medicine is a crucial part of protecting both pets and humans from infestations and transmission of vector-borne diseases.

Methods

The efficacy of a novel endectocide, Credelio Quattro, containing lotilaner, moxidectin, praziquantel, and pyrantel, was evaluated in four masked studies: one against Ctenocephalides felis and three against the dose-limiting tick Rhipicephalus sanguineus. Dogs were orally administered placebo, Credelio Quattro™, lotilaner only (Credelio™, Study 2), or pyrantel only (Study 2) in a fed state on Day 0. Experimental infestations with C. felis were conducted on Days −1, 6, 13, 20, 29, and 35 with 100 adult fleas. Fleas were removed and categorized as either live or dead 24 h post-treatment and 24 h post-infestation thereafter. Experimental infestations with R. sanguineus were conducted on Days −2, 5, 12, 19, and 30 with 50 adult ticks. Ticks were removed and categorized as attached or unattached and then live or dead 48 h post-treatment and 48 h post-infestation thereafter.

Results

Credelio Quattro demonstrated 100% (P < 0.0001) efficacy against C. felis, with no live fleas recovered at time points evaluated through 36 days post-treatment. Additionally, Credelio Quattro demonstrated 97.1–100% (P < 0.0001) efficacy through Day 30 against the established dose-limiting tick species, R. sanguineus. In Study 2, pyrantel demonstrated ≤ 46.6% (P ≥ 0.0601) efficacy while lotilaner provided ≥ 99.6% (P ≤ 0.0007) efficacy, confirming lotilaner as the acaricidal active ingredient in Credelio Quattro. Adverse events were reported in both treatment groups, including dermatitis, alopecia, lameness, and a chest wound. One dog in a Credelio Quattro treatment group experienced vomiting and bloody diarrhea that was considered possibly treatment-related.

Conclusions

These studies confirm the safety and effectiveness of a single dose of Credelio Quattro for the treatment and control of C. felis and R. sanguineus infestations on dogs for 1 month.

Graphical Abstract