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<p>In a prospective study of 15 patients with liver alveolar echinococcosis who underwent curative surgery, a strategy to reduce the recommended 2-year postoperative albendazole (ABZ) regimen was evaluated. Guided by negative positron emission tomography computed tomography (PET-CT) and magnetic resonance imaging (MRI) results at 1 year, ABZ was safely discontinued earlier (median 14&#xa0;months) in 10 patients, with no recurrence observed during the mean 47&#xa0;months of follow-up, indicating that postoperative ABZ may be safely shortened with careful imaging follow-up. Interestingly, a retrospective analysis of the rEm18AB antibody index showed that a negative index was not required for ABZ withdrawal, although a declining trend supported the decision.</p> Graphical Abstract <p></p>

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Is a shortened postoperative albendazole duration after curative surgery for alveolar echinococcosis possible? Results from a prospective multicenter study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月17日

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  • Paul Calame,
  • Carine Richou,
  • Oleg Blagosklonov,
  • Frederic Grenouillet,
  • Alexandra Heurgué,
  • Isabelle Villena,
  • Emilia Frentiu,
  • Celia Turco,
  • Gabriel Simon,
  • Alexandre Doussot,
  • Sophie Felix,
  • Florence Grenouillet,
  • Bruno Heyd,
  • Damien Montange,
  • Claire Vanlemmens,
  • Pascal Chavanet,
  • Frédéric Dalle,
  • Sandrine Gohier,
  • Anne Minello,
  • Jérôme Dumortier,
  • Martine Wallon,
  • Anne Debourgogne,
  • Valérie Laurent,
  • Lorraine Letranchant,
  • Marie Machouart,
  • Jérôme Watelet,
  • Cathy Chemla,
  • Thomas Feron,
  • Christine Hoeffel,
  • Daniele Sommacale,
  • Gerard Thiéfin,
  • Dominique-Angèle Vuitton,
  • Solange Bresson-Hadni

摘要

In a prospective study of 15 patients with liver alveolar echinococcosis who underwent curative surgery, a strategy to reduce the recommended 2-year postoperative albendazole (ABZ) regimen was evaluated. Guided by negative positron emission tomography computed tomography (PET-CT) and magnetic resonance imaging (MRI) results at 1 year, ABZ was safely discontinued earlier (median 14 months) in 10 patients, with no recurrence observed during the mean 47 months of follow-up, indicating that postoperative ABZ may be safely shortened with careful imaging follow-up. Interestingly, a retrospective analysis of the rEm18AB antibody index showed that a negative index was not required for ABZ withdrawal, although a declining trend supported the decision.

Graphical Abstract