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<p>Antidepressant drugs, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are known to induce sexual dysfunction as a side effect. Duloxetine (DLX) and Avanafil (AVN) are simultaneously determined in their pure state and laboratory-prepared mixtures by two novel, environmentally friendly spectrophotometric methods. The first method was based on second order derivatives while the second method is based on first derivative dual-wavelength. In method I, the linearity range was found to be 0.5–12&#xa0;µg/mL and 1–12&#xa0;µg/mL with limit of detection 0.15&#xa0;µg/mL and 0.27&#xa0;µg/mL for DLX and AVN, respectively. In method II, the linearity range was found to be 1–10&#xa0;µg/mL for both drugs with limit of detection 0.18&#xa0;µg/mL and 0.21&#xa0;µg/mL for DLX and AVN, respectively. The validation of these approaches meets the International Council for Harmonization’s (ICH) standards. Furthermore, three current ecological tools namely the Eco-Scale, GAPI, and AGREE were used to evaluate the proposed method’s greenness. The sustainability characteristics of the proposed method were also assessed using the Blue Applicability Grade Index (BAGI), a recently developed metric for assessing the practicality (blueness) of procedures.</p>

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Novel spectrophotometric methods for concurrent assessment of duloxetine and avanafil in their binary mixture using derivative spectroscopy: greenness-blueness evaluation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月2日

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  • Hadeer A. Elhamdy,
  • Sayed M. Derayea,
  • Khalid M. Badr El-Din,
  • Mohamed Oraby

摘要

Antidepressant drugs, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are known to induce sexual dysfunction as a side effect. Duloxetine (DLX) and Avanafil (AVN) are simultaneously determined in their pure state and laboratory-prepared mixtures by two novel, environmentally friendly spectrophotometric methods. The first method was based on second order derivatives while the second method is based on first derivative dual-wavelength. In method I, the linearity range was found to be 0.5–12 µg/mL and 1–12 µg/mL with limit of detection 0.15 µg/mL and 0.27 µg/mL for DLX and AVN, respectively. In method II, the linearity range was found to be 1–10 µg/mL for both drugs with limit of detection 0.18 µg/mL and 0.21 µg/mL for DLX and AVN, respectively. The validation of these approaches meets the International Council for Harmonization’s (ICH) standards. Furthermore, three current ecological tools namely the Eco-Scale, GAPI, and AGREE were used to evaluate the proposed method’s greenness. The sustainability characteristics of the proposed method were also assessed using the Blue Applicability Grade Index (BAGI), a recently developed metric for assessing the practicality (blueness) of procedures.