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<p>In this study, a new nanocomposite comprising 4-(2-Aminoethyl)-morpholine, an organic catalyst, was prepared on the surface of silica. The absence of metal in the catalyst structure contributes to its environmental friendliness. This novel nanocatalyst was used for multi-component reactions (MCRs). Having a nano size for the composite enhances the contact between the raw materials and the catalytic surface, leading to significant advancement in the reaction. The synthesized composite was identified and evaluated using FT-IR, EDX, EDX-Mapping, TGA, XRD, BET, TEM, and FE-SEM analysis. The characteristic analysis confirmed the synthesis of both nano-silica/4-(2-Aminoethyl)-morpholine catalyst and polyhydroquinoline. The composite’s catalytic properties for synthesizing some polyhydroquinoline derivatives were investigated, yielding promising and remarkable results with high 95% yields and short reaction times. The antibacterial properties of the synthesized compounds were also examined against four types of pathogenic bacteria. The highest inhibitory effect was attributed to the compound Ethyl-4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate exhibited the highest antibacterial properties.</p>

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Nanao/organocatalyat SiO2/4-(2-Aminoethyl)-morpholine as a new, reusable, and efficacious catalyst for the synthesis of polyhydroquinolines derivatives and antibacterially active evaluation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月3日

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  • Leila Amiri-Zirtol,
  • Zahra Karimi,
  • Javad Farahbakhsh,
  • Ahmad Gholami,
  • Seyedeh Narjes Abootalebi

摘要

In this study, a new nanocomposite comprising 4-(2-Aminoethyl)-morpholine, an organic catalyst, was prepared on the surface of silica. The absence of metal in the catalyst structure contributes to its environmental friendliness. This novel nanocatalyst was used for multi-component reactions (MCRs). Having a nano size for the composite enhances the contact between the raw materials and the catalytic surface, leading to significant advancement in the reaction. The synthesized composite was identified and evaluated using FT-IR, EDX, EDX-Mapping, TGA, XRD, BET, TEM, and FE-SEM analysis. The characteristic analysis confirmed the synthesis of both nano-silica/4-(2-Aminoethyl)-morpholine catalyst and polyhydroquinoline. The composite’s catalytic properties for synthesizing some polyhydroquinoline derivatives were investigated, yielding promising and remarkable results with high 95% yields and short reaction times. The antibacterial properties of the synthesized compounds were also examined against four types of pathogenic bacteria. The highest inhibitory effect was attributed to the compound Ethyl-4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate exhibited the highest antibacterial properties.