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Background <p>Patients with stroke would experience upper limb dysfunction, leading to functional impairments in daily living and placing a burden on society and families. Repetitive transcranial magnetic stimulation (rTMS), a noninvasive neuromodulation tool, has been shown to upper limb dysfunction. However, the clinical efficacy and the underlying neurophysiological mechanisms of optimal intensity of rTMS to promote motor recovery of stroke patients with upper limb function need further investigations. This study aims to investigate the changes in the brain neurophysiological mechanisms ranging from cortical oscillatory activity to the effectiveness of the complex network after low-frequency (LF) and high-frequency (HF) rTMS on motor areas of patient post-stroke.</p> Method <p>A total of 42 stroke patients with upper limb dysfunction will be randomized into high-frequency (HF) rTMS group and low-frequency (LF) rTMS group (1:1 ratio). The HF-rTMS group will use 90% resting motor threshold (RMT), 10&#xa0;Hz acting with the ipsilesional M1 for a total of 1500 pulses for 2&#xa0;weeks, and the LF-rTMS group acting on the contralesional M1 with the same parameters, except that 1&#xa0;Hz is used. The National Institutes of Health Stroke Scale (NIHSS), the motor deficit (the Fugl–Meyer Assessment Upper Extremity (FMA-UE)), Modified Barthel Index (MBI), and resting-state electroencephalogram (EEG) signals will be obtained at the baseline and within 1 week after the rTMS.</p> Discussion <p>This study will contribute to the understanding of the neurophysiological changes in the brain corresponding to the clinical effects of HF- and LF-rTMS in patients with stroke.</p> Trial registration <p>ChiCTR2200065639. Registered in November 2022.</p>

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Effects of repetitive transcranial magnetic stimulation on electroencephalographical measures of poststroke upper limb dysfunction: study protocol for a randomized controlled trial

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  • 发表日期：

    2026年3月16日

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  • Bo Chen,
  • Heng Ming Wu,
  • Sam C. C. Chan

摘要

Background

Patients with stroke would experience upper limb dysfunction, leading to functional impairments in daily living and placing a burden on society and families. Repetitive transcranial magnetic stimulation (rTMS), a noninvasive neuromodulation tool, has been shown to upper limb dysfunction. However, the clinical efficacy and the underlying neurophysiological mechanisms of optimal intensity of rTMS to promote motor recovery of stroke patients with upper limb function need further investigations. This study aims to investigate the changes in the brain neurophysiological mechanisms ranging from cortical oscillatory activity to the effectiveness of the complex network after low-frequency (LF) and high-frequency (HF) rTMS on motor areas of patient post-stroke.

Method

A total of 42 stroke patients with upper limb dysfunction will be randomized into high-frequency (HF) rTMS group and low-frequency (LF) rTMS group (1:1 ratio). The HF-rTMS group will use 90% resting motor threshold (RMT), 10 Hz acting with the ipsilesional M1 for a total of 1500 pulses for 2 weeks, and the LF-rTMS group acting on the contralesional M1 with the same parameters, except that 1 Hz is used. The National Institutes of Health Stroke Scale (NIHSS), the motor deficit (the Fugl–Meyer Assessment Upper Extremity (FMA-UE)), Modified Barthel Index (MBI), and resting-state electroencephalogram (EEG) signals will be obtained at the baseline and within 1 week after the rTMS.

Discussion

This study will contribute to the understanding of the neurophysiological changes in the brain corresponding to the clinical effects of HF- and LF-rTMS in patients with stroke.

Trial registration

ChiCTR2200065639. Registered in November 2022.