Scholarlink

Background <p>Chronic pain (CP) is among the most common medical conditions, is the leading cause of disability, and is often refractory to medical treatment. The CDC and the American College of Physicians recommend nonopioid and nonpharmacologic treatment as first-line strategies, including cognitive-behavioral therapy (CBT), mindfulness-based interventions (MBI), and movement-focused interventions (MFI); however, only 3% of people with chronic pain (CP) have access to these evidence-based treatments. Patients from historically minoritized populations and those speaking languages other than English are particularly underserved and may go untreated. Stigma regarding CP and interventions to manage it present additional obstacles.</p> Methods <p>The Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE) study evaluates a blend of these non-pharmacologic, evidence-based interventions using a pragmatic, parallel, two-arm RCT comparing intervention participants with wait-list controls. The INSPIRE intervention includes a 12-week curriculum delivered via a multilingual mobile app paired with weekly telehealth coaching. The primary outcome will be the “Pain, Enjoyment, and General Activity (PEG)” scores at 3 months. Secondary outcomes include PEG scores at 6 and 12 months, physical functioning, quality of life, sleep, depression, anxiety, and global satisfaction with treatment at 3, 6, and 12 months. Primary mediators to be examined include pain cognitions and health behaviors. Secondary mediators may include stigma and isolation, trust in healthcare providers, and both engagement and satisfaction with the INSPIRE intervention. The intention-to-treat primary analysis will be conducted with covariates including baseline measures of pain, anxiety, and physical function.</p> Discussion <p>The full RCT protocol and intervention details are provided following the SPIRIT guidelines. Implications for improving treatment access via culturally and linguistically tailored digital health interventions are discussed along with the potential for health coaching to drive mobile app engagement.</p> Trial registration <p>ClinicalTrials.gov ID NCT06183281. Trial registration data set can be found here: <a href="https://clinicaltrials.gov/study/NCT06183281">https://clinicaltrials.gov/study/NCT06183281</a> and in Additional file 1.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Integrating nonpharmacologic strategies for pain with Inclusion, Respect, and Equity (INSPIRE): a digital health study protocol for a pragmatic multisite randomized controlled trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月8日

查看全文
  • Jesse Ristau,
  • Agatha Okobi,
  • Matthew J. Miller,
  • Jing Cheng,
  • Sibel Deviren,
  • Eleanor Bimla Schwarz,
  • Tess Fairchild,
  • Janice Y. Tsoh,
  • Adrian Aguilera,
  • Cindy J. Zheng-Huang,
  • Jason M. Satterfield

摘要

Background

Chronic pain (CP) is among the most common medical conditions, is the leading cause of disability, and is often refractory to medical treatment. The CDC and the American College of Physicians recommend nonopioid and nonpharmacologic treatment as first-line strategies, including cognitive-behavioral therapy (CBT), mindfulness-based interventions (MBI), and movement-focused interventions (MFI); however, only 3% of people with chronic pain (CP) have access to these evidence-based treatments. Patients from historically minoritized populations and those speaking languages other than English are particularly underserved and may go untreated. Stigma regarding CP and interventions to manage it present additional obstacles.

Methods

The Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE) study evaluates a blend of these non-pharmacologic, evidence-based interventions using a pragmatic, parallel, two-arm RCT comparing intervention participants with wait-list controls. The INSPIRE intervention includes a 12-week curriculum delivered via a multilingual mobile app paired with weekly telehealth coaching. The primary outcome will be the “Pain, Enjoyment, and General Activity (PEG)” scores at 3 months. Secondary outcomes include PEG scores at 6 and 12 months, physical functioning, quality of life, sleep, depression, anxiety, and global satisfaction with treatment at 3, 6, and 12 months. Primary mediators to be examined include pain cognitions and health behaviors. Secondary mediators may include stigma and isolation, trust in healthcare providers, and both engagement and satisfaction with the INSPIRE intervention. The intention-to-treat primary analysis will be conducted with covariates including baseline measures of pain, anxiety, and physical function.

Discussion

The full RCT protocol and intervention details are provided following the SPIRIT guidelines. Implications for improving treatment access via culturally and linguistically tailored digital health interventions are discussed along with the potential for health coaching to drive mobile app engagement.

Trial registration

ClinicalTrials.gov ID NCT06183281. Trial registration data set can be found here: https://clinicaltrials.gov/study/NCT06183281 and in Additional file 1.