Background <p>Knee osteoarthritis (OA) is a prevalent degenerative condition among older women, frequently causing pain, decreased mobility, and reduced quality of life. As the global population ages, effective and accessible non-pharmacological interventions are urgently needed. This randomized controlled trial aims to evaluate the clinical and statistical effects of a 12-week BodyBalance exercise program on symptoms and complications associated with OA in older women.</p> Methods <p>A total of 40 older women aged 60–80 years with clinically diagnosed knee OA will be randomly assigned to either the intervention group or the control group. The intervention group will participate in a supervised BodyBalance training program, while the control group will maintain their usual activities without any structured exercise. Outcomes include evaluations of knee pain, balance, postural control, lower limb muscle strength, proprioception (knee and ankle), fear of falling, and overall quality of life.</p> Discussion <p>The study is expected to demonstrate that BodyBalance significantly improves balance, reduces pain, and enhances functional mobility in older women with OA compared to no intervention. These findings may support the clinical adoption of mind–body exercise as a cost-effective strategy for improving independence and well-being in the aging population.</p> Trial registration <p><a href="https://irct.behdasht.gov.ir/trial/68467">https://irct.behdasht.gov.ir/trial/68467</a>. Registered on 15 April 2023. Retrospectively registered.</p>