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<p>Skeletal muscle development relies on tightly coordinated transcriptional programs, yet the contribution of long non-coding RNAs (lncRNAs) to myogenesis remains largely unexplored. We previously demonstrated that the transcription factor TAp63γ is upregulated during myoblast differentiation and regulates the expression of genes involved in early stages of myogenic maturation. Here, combining transcriptome profiling with p63 ChIP-seq analysis in differentiating mouse myoblasts, we identify the lncRNA <i>Airn</i> as a direct transcriptional target of TAp63γ. Our findings position Airn as a previously unrecognized regulator of myogenic commitment that modulates both <i>MyoD</i> and <i>MyoG</i> expression at the mRNA and protein levels. Our work uncovers a novel TAp63γ–<i>Airn</i> axis essential for proper skeletal muscle differentiation and with potential relevance to muscle-wasting diseases.</p>

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A novel TAp63γ–Airn regulatory axis governs early myogenic gene networks

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月28日

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  • Veronica Ciuffoli,
  • Maria Cristina Piro,
  • Alessia Angelin,
  • Giulio Colasanto,
  • Huiqing Zhou,
  • Jieqiong Qu,
  • Anna Maria Lena,
  • Gerry Melino,
  • Eleonora Candi

摘要

Skeletal muscle development relies on tightly coordinated transcriptional programs, yet the contribution of long non-coding RNAs (lncRNAs) to myogenesis remains largely unexplored. We previously demonstrated that the transcription factor TAp63γ is upregulated during myoblast differentiation and regulates the expression of genes involved in early stages of myogenic maturation. Here, combining transcriptome profiling with p63 ChIP-seq analysis in differentiating mouse myoblasts, we identify the lncRNA Airn as a direct transcriptional target of TAp63γ. Our findings position Airn as a previously unrecognized regulator of myogenic commitment that modulates both MyoD and MyoG expression at the mRNA and protein levels. Our work uncovers a novel TAp63γ–Airn axis essential for proper skeletal muscle differentiation and with potential relevance to muscle-wasting diseases.