Scholarlink

Background <p>Transposable elements (TEs) are an abundant and crucial regulatory resource in the human genome. Serving as alternative promoters, TEs can be reactivated and produce TE-initiated transcripts, which play importance roles in early development and differentiated tissues. However, the prevalence and function of TE-initiated transcription in human development are poorly characterized.</p> Results <p>We identify 14,164 TE-initiated transcripts across 40 human body sites and embryonic stem cells. Among TE-initiated transcripts, 80% are activated in a tissue-specific manner. TEs with tissue-specific transcription factor binding motifs are enriched in particular tissues. Additionally, approximately half of TE-derived TSSs are primates-specific. Notably, 312 primates-specific TE-derived TSSs are found to create novel tissue-specific gene expression patterns during evolution.</p> Conclusions <p>Our results characterize the global profile of TE-initiated transcription and enhance our understanding of TE contribution to the primate-specific gene regulatory networks in human development.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Transposable elements drive species-specific and tissue-specific transcriptomes in human development

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月4日

查看全文
  • Yun Zhang,
  • Jianqi She,
  • Xueyan Hu,
  • Yueqi Jin,
  • Jiaming Zhao,
  • Songyan Hou,
  • Changyu Tao,
  • Minghao Du,
  • Ence Yang

摘要

Background

Transposable elements (TEs) are an abundant and crucial regulatory resource in the human genome. Serving as alternative promoters, TEs can be reactivated and produce TE-initiated transcripts, which play importance roles in early development and differentiated tissues. However, the prevalence and function of TE-initiated transcription in human development are poorly characterized.

Results

We identify 14,164 TE-initiated transcripts across 40 human body sites and embryonic stem cells. Among TE-initiated transcripts, 80% are activated in a tissue-specific manner. TEs with tissue-specific transcription factor binding motifs are enriched in particular tissues. Additionally, approximately half of TE-derived TSSs are primates-specific. Notably, 312 primates-specific TE-derived TSSs are found to create novel tissue-specific gene expression patterns during evolution.

Conclusions

Our results characterize the global profile of TE-initiated transcription and enhance our understanding of TE contribution to the primate-specific gene regulatory networks in human development.