Scholarlink

<p>Driver mutations in <i>IDH1</i> and <i>IDH2</i> are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant <i>IDH1</i> is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant <i>IDH1</i> locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月26日

查看全文
  • William Cross,
  • Iben Lyskjær,
  • Christopher Davies,
  • Abigail Bunkum,
  • Ana Maia Rocha,
  • Tom Lesluyes,
  • Fernanda Amary,
  • Roberto Tirabosco,
  • Cristina Naceur-Lombardelli,
  • Sonya Hessey,
  • Kai-Keen Shiu,
  • John Bridgewater,
  • Daniel Hochhauser,
  • Martin Forster,
  • Siow-Ming Lee,
  • Tanya Ahmad,
  • Dionysis Papadatos-Pastos,
  • Sam Janes,
  • Katey Enfield,
  • Nicholas McGranahan,
  • Ariana Huebner,
  • Sergio Quezada,
  • Stephan Beck,
  • Peter Parker,
  • Tariq Enver,
  • Robert E. Hynds,
  • David R. Pearce,
  • Mary Falzon,
  • Ian Proctor,
  • Ron Sinclair,
  • Chi-wah Lok,
  • Zoe Rhodes,
  • David Moore,
  • Teresa Marafioti,
  • Miriam Mitchison,
  • Peter Ellery,
  • Monica Sivakumar,
  • Mark Linch,
  • Sebastian Brandner,
  • Andrew Rowan,
  • Crispin Hiley,
  • Selvaraju Veeriah,
  • Heather Shaw,
  • Gert Attard,
  • Antonia Toncheva,
  • Paulina Prymas,
  • Thomas B. K. Watkins,
  • Chris Bailey,
  • Carlos Martinez Ruiz,
  • Kevin Litchfield,
  • Maise Al-Bakir,
  • Nnenna Kanu,
  • Sophia Ward,
  • Emilia Lim,
  • James Reading,
  • Benny Chain,
  • Blanca Trujillo Alba,
  • Tom Watkins,
  • Melek Akay,
  • Dhruva Biswas,
  • Oriol Pich,
  • Michelle Dietzen,
  • Clare Puttick,
  • Emma Colliver,
  • Alistair Magness,
  • Mihaela Angelova,
  • James Black,
  • Olivia Lucas,
  • William Hill,
  • Wing-Kin Liu,
  • Alexander Frankell,
  • Neil Magno,
  • Foteini Athanasopoulou,
  • Roberto Salgado,
  • Claudia Lee,
  • Kristiana Grigoriadis,
  • Othman Al-Sawaf,
  • Takahiro Karasaki,
  • Imran Noorani,
  • Sarah Benafif,
  • Vittorio Barbe,
  • Supreet Bola,
  • Osvaldas Vainauskas,
  • Anna Wingate,
  • Daniel Wetterskog,
  • Mahedi Hasan,
  • Stefano Lise,
  • GianMarco Leone,
  • Anuradha Jayaram,
  • Constantine Alifrangis,
  • Ursula McGovern,
  • Kerstin Thol,
  • Samuel Gamble,
  • Seng Kuong Ung,
  • Teerapon Sahwangarrom,
  • Claudia Peinador Marin,
  • Sophia Wong,
  • Piotr Pawlik,
  • Jie Min Lam,
  • Corentin Richard,
  • Roberto Vendramin,
  • Krijn Dijkstra,
  • Jayant Rane,
  • Jerome Nicod,
  • Rija Zaidi,
  • Faye Gishen,
  • Adrian Tookman,
  • Paddy Stone,
  • Caroline Stirling,
  • Samra Turajlic,
  • James Larkin,
  • Lisa Pickering,
  • Andrew Furness,
  • Kate Young,
  • Will Drake,
  • Kim Edmonds,
  • Nikki Hunter,
  • Mary Mangwende,
  • Karla Pearce,
  • Lauren Lewis Au,
  • Lavinia Spain,
  • Scott Shepherd,
  • Haixi Yan,
  • Ben Shum,
  • Zayd Tippu,
  • Brian Hanley,
  • Charlotte Spencer,
  • Max Emmerich,
  • Camille Gerard,
  • Andreas Michael Schmitt,
  • Lyra Del Rosario,
  • Eleanor Carlyle,
  • Charlotte Lewis,
  • Lucy Holt,
  • Analyn Lucanas,
  • Molly O’Flaherty,
  • Steve Hazell,
  • Hardeep Mudhar,
  • Christina Messiou,
  • Arash Latifoltojar,
  • Annika Fendler,
  • Fiona Byrne,
  • Husayn Pallinkonda,
  • Irene Lobon,
  • Alex Coulton,
  • Anne Laure Cattin,
  • Daqi Deng,
  • Geoffrey Hugang Feng,
  • Andew Rowan,
  • Nadia Yousaf,
  • Sanjay Popat,
  • Olivia Curtis,
  • Charlotte Milner-Watts,
  • Gordon Stamp,
  • Emma Nye,
  • Aida Murra,
  • Justine Korteweg,
  • Denise Kelly,
  • Lauren Terry,
  • Jennifer Biano,
  • Kema Peat,
  • Kayleigh Kelly,
  • Peter Hill,
  • Debra Josephs,
  • Sheeba Irshad,
  • James Spicer,
  • Ula Mahadeva,
  • Anna Green,
  • Ruby Stewart,
  • Natasha Wright,
  • Georgina Pulman,
  • Ruxandra Mitu,
  • Sherene Phillips-Boyd,
  • Deborah Enting,
  • Sarah Rudman,
  • Sharmistha Ghosh,
  • Lena Karapagniotou,
  • Elias Pintus,
  • Andrew Tutt,
  • Sarah Howlett,
  • James Brenton,
  • Carlos Caldas,
  • Rebecca Fitzgerald,
  • Merche Jimenez-Linan,
  • Elena Provenzano,
  • Alison Cluroe,
  • Anna Paterson,
  • Sarah Aitken,
  • Kieren Allinson,
  • Grant Stewart,
  • Ultan McDermott,
  • Emma Beddowes,
  • Tim Maughan,
  • Olaf Ansorge,
  • Peter Campbell,
  • Patricia Roxburgh,
  • Sioban Fraser,
  • Kevin Blyth,
  • John Le Quesne,
  • Matthew Krebs,
  • Fiona Blackhall,
  • Yvonne Summers,
  • Pedro Oliveira,
  • Ana Ortega-Franco,
  • Caroline Dive,
  • Fabio Gomes,
  • Mat Carter,
  • Jo Dransfield,
  • Anne Thomas,
  • Dean Fennell,
  • Jacqui Shaw,
  • Babu Naidu,
  • Shobhit Baijal,
  • Bruce Tanchel,
  • Gerald Langman,
  • Andrew Robinson,
  • Martin Collard,
  • Peter Cockcroft,
  • Charlotte Ferris,
  • Hollie Bancroft,
  • Amy Kerr,
  • Gary Middleton,
  • Joanne Webb,
  • Salma Kadiri,
  • Peter Colloby,
  • Bernard Olisemeke,
  • Rodelaine Wilson,
  • Ian Tomlinson,
  • Sanjay Jogai,
  • Samantha Holden,
  • Tania Fernandes,
  • Iain McNeish,
  • Blanche Hampton,
  • Mairead McKenzie,
  • Allan Hackshaw,
  • Abby Sharp,
  • Kitty Chan,
  • Laura Farrelly,
  • Hayley Bridger,
  • Rachel Leslie,
  • Mariam Jamal-Hanjani,
  • Charles Swanton,
  • Nischalan Pillay,
  • Simone Zaccaria,
  • Adrienne M. Flanagan,
  • Peter Van Loo

摘要

Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.