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<p>The field of single-cell biology is growing rapidly, generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal, and DISCO allow researchers to access large volumes of curated datasets, including more than just scRNA-seq data. These resources have created an opportunity to build and expand the computational biology ecosystem to develop tools necessary for data reuse and for extracting novel biological insights. We highlight achievements made so far, areas where further development is needed, and specific challenges that need to be overcome.</p>

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Insights, opportunities, and challenges provided by large cell atlases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月20日

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  • Martin Hemberg,
  • Federico Marini,
  • Shila Ghazanfar,
  • Ahmad Al Ajami,
  • Najla Abassi,
  • Benedict Anchang,
  • Bérénice A. Benayoun,
  • Yue Cao,
  • Ken Chen,
  • Yesid Cuesta-Astroz,
  • Zachary DeBruine,
  • Calliope A. Dendrou,
  • Iwijn De Vlaminck,
  • Katharina Imkeller,
  • Ilya Korsunsky,
  • Alex R. Lederer,
  • Jessica Jingyi Li,
  • Pieter Meysman,
  • Clint L. Miller,
  • Kerry A. Mullan,
  • Uwe Ohler,
  • Pratibha Panwar,
  • Nikolaos Patikas,
  • Jonas Schuck,
  • Jacqueline H. Y. Siu,
  • Timothy J. Triche Jr.,
  • Alex Tsankov,
  • Sander W. van der Laan,
  • Masanao Yajima,
  • Jean Yang,
  • Fabio Zanini,
  • Ivana Jelic

摘要

The field of single-cell biology is growing rapidly, generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal, and DISCO allow researchers to access large volumes of curated datasets, including more than just scRNA-seq data. These resources have created an opportunity to build and expand the computational biology ecosystem to develop tools necessary for data reuse and for extracting novel biological insights. We highlight achievements made so far, areas where further development is needed, and specific challenges that need to be overcome.