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<p>Moving from a one-size-fits-all to an individual approach in precision medicine requires a deeper understanding of disease molecular mechanisms. Especially in heterogeneous complex diseases such as inflammatory bowel disease (IBD), better molecular stratification will help select the correct therapy. For this, we build end-to-end biologically sparsified neural network architectures for IBD subtyping based on whole exome sequence representations with gene-level and variant-level resolution. By moving beyond univariate methods, we capitalize on the model’s ability to extract complex molecular patterns to improve prediction. Model interpretation identifies the most predictive pathways, genes, and variants, uncovering important intestinal barrier, immunological, and microbiome factors.</p>

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Explainable deep learning for stratified medicine in inflammatory bowel disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月24日

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  • Nora Verplaetse,
  • Piero Fariselli,
  • Yves Moreau,
  • Daniele Raimondi

摘要

Moving from a one-size-fits-all to an individual approach in precision medicine requires a deeper understanding of disease molecular mechanisms. Especially in heterogeneous complex diseases such as inflammatory bowel disease (IBD), better molecular stratification will help select the correct therapy. For this, we build end-to-end biologically sparsified neural network architectures for IBD subtyping based on whole exome sequence representations with gene-level and variant-level resolution. By moving beyond univariate methods, we capitalize on the model’s ability to extract complex molecular patterns to improve prediction. Model interpretation identifies the most predictive pathways, genes, and variants, uncovering important intestinal barrier, immunological, and microbiome factors.