Scholarlink

Research question <p>In human and animal reproduction, the majority of the ovary’s reproductive potential is lost before puberty. In order to survive, oocytes must interact with stromal cells. However, the specific distribution and role of ovarian immune cells compared to lymphatic organs is still indistinct.</p> Design <p>Immune cell composition in the ovary, spleen, and lymph nodes was analyzed in six-week-old female C57BL/6 mice using flow cytometry. The following populations were examined: macrophages, dendritic cells, natural killer cells, NKT cells, B cells, T cells, CD4 + T cells and CD8 + T cells.</p> Results <p>Only 3% of the cells that make up the ovary are immune cells. Ovarian immune cells consisted of natural killer cells (24%), T cells including CD4+- and CD8 + T cells (21%), macrophages (17%), dendritic cells (7%), NKT- and B cells (each 11%). In contrast, spleen and lymph nodes were dominated by B and T cells (spleen: 56% and 32%; lymph nodes: 33% and 62%).</p> Conclusions <p>Ovarian immune cells are scarce in healthy young mice. Apart from a relatively large T-cell population, the ovarian immune compartment is dominated by innate immune cells, particularly macrophages and natural killer cells, which is in line with the multifarious role of macrophages in multiple aspects of ovarian physiology. In contrast, adaptive immune cells such as B and T lymphocytes are primarily enriched in secondary lymphoid organs, including the spleen and lymph nodes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Making themselves scarce: immune cells in the ovary

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月26日

查看全文
  • Bettina Toth,
  • Elisabeth Reiser,
  • Samuel M. Vorbach,
  • Monika Frank,
  • Lea Huber,
  • Thomas Seppi,
  • Elisabeth Pechriggl,
  • Bettina Böttcher,
  • Katharina Feil,
  • Marko Konschake,
  • Ute Ganswindt,
  • Michael Niederwanger

摘要

Research question

In human and animal reproduction, the majority of the ovary’s reproductive potential is lost before puberty. In order to survive, oocytes must interact with stromal cells. However, the specific distribution and role of ovarian immune cells compared to lymphatic organs is still indistinct.

Design

Immune cell composition in the ovary, spleen, and lymph nodes was analyzed in six-week-old female C57BL/6 mice using flow cytometry. The following populations were examined: macrophages, dendritic cells, natural killer cells, NKT cells, B cells, T cells, CD4 + T cells and CD8 + T cells.

Results

Only 3% of the cells that make up the ovary are immune cells. Ovarian immune cells consisted of natural killer cells (24%), T cells including CD4+- and CD8 + T cells (21%), macrophages (17%), dendritic cells (7%), NKT- and B cells (each 11%). In contrast, spleen and lymph nodes were dominated by B and T cells (spleen: 56% and 32%; lymph nodes: 33% and 62%).

Conclusions

Ovarian immune cells are scarce in healthy young mice. Apart from a relatively large T-cell population, the ovarian immune compartment is dominated by innate immune cells, particularly macrophages and natural killer cells, which is in line with the multifarious role of macrophages in multiple aspects of ovarian physiology. In contrast, adaptive immune cells such as B and T lymphocytes are primarily enriched in secondary lymphoid organs, including the spleen and lymph nodes.