Scholarlink

Background <p>Recently, silver nanoparticles (Ag-NPs) were shown to provoke oxidative stress through the release of reactive oxygen species and consequently induce cell damage. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have anti-inflammatory and antioxidant effects, indicating that they ameliorate Ag-NPs-induced ovarian toxicity.</p> Objective <p>This study aimed to assess how well CS-SeNPs counteract the damaging effects of Ag-NPs on the ovarian&#xa0;tissue&#xa0;of adult female albino rats.</p> Methods <p>Forty mature female albino rats were divided into four equal groups: for 60&#xa0;days, Group I (control) was given 0.5&#xa0;ml/kg of distilled water; Group II was given Ag-NPs orally (100&#xa0;mg/kg); Group III was given Ag-NPs orally (100&#xa0;mg/kg/d) plus CS-SeNPs (0.5&#xa0;mg/kg/d); and Group IV was given only CS-SeNPs orally (0.5&#xa0;mg/kg/d). All the ovarian tissues were&#xa0;removed and&#xa0;underwent immunohistochemical, histological, and biochemical analyses.</p> Results <p>Ag-NPs-exposed rats revealed a marked reduction in reduced glutathione (GSH) and superoxide dismutase (SOD). Numerous histopathological alterations were found along with a significant increase in PCNA- and Caspase-3-immunoreactive cells. Most of these alterations were successfully ameliorated by CS-SeNPs, as indicated by marked increases in GSH and SOD.</p> Conclusion <p>CS-SeNPs ameliorate the toxic effects of Ag-NPs on the ovarian&#xa0;tissue&#xa0;of adult female albino rats.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月7日

查看全文
  • Omnia E. Shalaby,
  • Yasmine H. Ahmed,
  • Aya M. Mekkawy,
  • Mohamed Y. Mahmoud,
  • G. A. Elbargeesy

摘要

Background

Recently, silver nanoparticles (Ag-NPs) were shown to provoke oxidative stress through the release of reactive oxygen species and consequently induce cell damage. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have anti-inflammatory and antioxidant effects, indicating that they ameliorate Ag-NPs-induced ovarian toxicity.

Objective

This study aimed to assess how well CS-SeNPs counteract the damaging effects of Ag-NPs on the ovarian tissue of adult female albino rats.

Methods

Forty mature female albino rats were divided into four equal groups: for 60 days, Group I (control) was given 0.5 ml/kg of distilled water; Group II was given Ag-NPs orally (100 mg/kg); Group III was given Ag-NPs orally (100 mg/kg/d) plus CS-SeNPs (0.5 mg/kg/d); and Group IV was given only CS-SeNPs orally (0.5 mg/kg/d). All the ovarian tissues were removed and underwent immunohistochemical, histological, and biochemical analyses.

Results

Ag-NPs-exposed rats revealed a marked reduction in reduced glutathione (GSH) and superoxide dismutase (SOD). Numerous histopathological alterations were found along with a significant increase in PCNA- and Caspase-3-immunoreactive cells. Most of these alterations were successfully ameliorated by CS-SeNPs, as indicated by marked increases in GSH and SOD.

Conclusion

CS-SeNPs ameliorate the toxic effects of Ag-NPs on the ovarian tissue of adult female albino rats.