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<p>High-dimensional gene expression datasets pose a major challenge in cancer classification due to redundancy, noise, and the risk of overfitting. To address these issues, this study proposes a hybrid framework that integrates the Dung Beetle Optimizer (DBO) for feature selection with Support Vector Machines (SVM) for classification. DBO, a recently developed nature-inspired algorithm, effectively identifies informative and non-redundant subsets of genes by simulating dung beetles’ foraging, rolling, obstacle avoidance, stealing, and breeding behaviors. The selected features are then classified using SVM with Radial Basis Function (RBF) kernels, which provide robust decision boundaries even in high-dimensional spaces. Extensive experiments were conducted on publicly available cancer-related gene expression datasets, covering binary, ternary, and quaternary classification tasks. Results show that the proposed DBO-SVM framework achieves 97.4–98.0% accuracy on binary datasets and 84–88% accuracy on multiclass datasets, with balanced Precision, Recall, and F1-scores. These findings highlight the method’s ability to enhance classification performance while reducing computational cost and improving biological interpretability. The proposed hybrid model demonstrates strong potential as an efficient and reliable tool for precision medicine and biomedical data analysis.</p>

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Optimizing accuracy and dimensionality: a swarm intelligence strategy for robust cancer genomics classification

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月18日

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  • Abrar Yaqoob,
  • Mushtaq Ahmad Mir,
  • R. Vijaya Lakshmi,
  • Tejaswini Pradhan,
  • G. V. V. Jagannadha Rao,
  • Ghanshyam G. Tejani,
  • Mohd Asif Shah

摘要

High-dimensional gene expression datasets pose a major challenge in cancer classification due to redundancy, noise, and the risk of overfitting. To address these issues, this study proposes a hybrid framework that integrates the Dung Beetle Optimizer (DBO) for feature selection with Support Vector Machines (SVM) for classification. DBO, a recently developed nature-inspired algorithm, effectively identifies informative and non-redundant subsets of genes by simulating dung beetles’ foraging, rolling, obstacle avoidance, stealing, and breeding behaviors. The selected features are then classified using SVM with Radial Basis Function (RBF) kernels, which provide robust decision boundaries even in high-dimensional spaces. Extensive experiments were conducted on publicly available cancer-related gene expression datasets, covering binary, ternary, and quaternary classification tasks. Results show that the proposed DBO-SVM framework achieves 97.4–98.0% accuracy on binary datasets and 84–88% accuracy on multiclass datasets, with balanced Precision, Recall, and F1-scores. These findings highlight the method’s ability to enhance classification performance while reducing computational cost and improving biological interpretability. The proposed hybrid model demonstrates strong potential as an efficient and reliable tool for precision medicine and biomedical data analysis.