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Background <p>Formaldehyde is a widely used fixative in medical practice. Accidental introduction into the human body can cause rapid protein coagulation, tissue necrosis, and severe systemic complications.</p> Case presentation <p>We report the case of a 60-year-old woman who received an inadvertent injection of formaldehyde into the inner lower lip during a minor salivary gland biopsy. The patient developed severe pain, labiomental erythema, and mucosal necrosis. She was initially managed with oral antibiotics, but the development of labiomental cellulitis necessitated hospitalization and intravenous antibiotic therapy, followed by surgical necrosectomy and tissue repair. Postoperative care included pro-healing ointment and bicarbonate mouth rinses, leading to complete recovery.</p> Conclusion <p>This rare case highlights that medical substance handling requires foolproof institutional safeguards. To prevent this severe complication, clinical facilities must ban the reuse of empty medication vials for chemical storage and enforce a strict dual-signature verification protocol prior to any local anesthetic infiltration.</p>

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Oral mucosa necrosis after accidental formaldehyde injection during salivary gland biopsy: case report of a rare preventable complication

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  • 发表日期：

    2026年7月1日

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  • Othmane Bouanani

摘要

Background

Formaldehyde is a widely used fixative in medical practice. Accidental introduction into the human body can cause rapid protein coagulation, tissue necrosis, and severe systemic complications.

Case presentation

We report the case of a 60-year-old woman who received an inadvertent injection of formaldehyde into the inner lower lip during a minor salivary gland biopsy. The patient developed severe pain, labiomental erythema, and mucosal necrosis. She was initially managed with oral antibiotics, but the development of labiomental cellulitis necessitated hospitalization and intravenous antibiotic therapy, followed by surgical necrosectomy and tissue repair. Postoperative care included pro-healing ointment and bicarbonate mouth rinses, leading to complete recovery.

Conclusion

This rare case highlights that medical substance handling requires foolproof institutional safeguards. To prevent this severe complication, clinical facilities must ban the reuse of empty medication vials for chemical storage and enforce a strict dual-signature verification protocol prior to any local anesthetic infiltration.