<p>Preterm premature rupture of membranes (PPROM) remains a leading cause of spontaneous preterm birth and neonatal morbidity, yet current clinical management strategies are limited. The fetal membranes, composed of the amnion and chorion, possess limited regenerative capacity once ruptured. Recent advances in biomaterials and tissue engineering have introduced promising therapeutic platforms capable of sealing membrane defects and promoting biological healing. These approaches offer significant advantages over traditional methods by providing dynamic, customizable, and biologically integrated solutions that better mimic the native extracellular matrix (ECM) and enhance tissue regeneration. This review summarizes biomaterial-based strategies, including collagen-based and natural ECM-derived materials, growth factor and drug delivery platforms, bioadhesives, membrane patch systems, and 3D bioprinting and in situ biofabrication. These materials are increasingly engineered to mimic native extracellular matrix properties, support cell migration, modulate local inflammation, and conform to the dynamic intrauterine environment. Preclinical studies in small and large animal models have demonstrated the feasibility of these systems in achieving defect closure, reducing inflammation, and prolonging gestation. Despite encouraging results, challenges remain related to biocompatibility, degradation kinetics, intrauterine delivery, and regulatory approval. This review underscores the potential of biomaterial strategies to transform the management of PPROM and outlines future directions for translating these technologies into clinical practice.</p>