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<p>Bone regeneration requires innovative solutions to enhance osteogenic differentiation and support effective tissue repair. This study presents a novel approach to bone tissue engineering by developing peptide-functionalized nanofibrous scaffolds (NFS). The fabrication of a blended hyaluronic acid (HA) and polydopamine (PD) scaffold functionalized with bone marrow mesenchymal stem cells (BMSCs)-affinity peptides (AP) designed to control magnesium ion (Mg) release, which supports BMSCs’ osteogenic differentiation and bone regeneration. Characterization studies, including fourier-transform infrared spectroscopy (FTIR) and morphological analysis, confirmed the hydrophilic properties of HA/PDNFS@BMSCs-AP scaffolds, which enhance cell adhesion and proliferation. In vitro and In vivo assessments revealed that the scaffolds significantly promote osteogenesis through AP-induced pathways such as extracellular signal-regulated kinase pathway (ERK) and Phosphatidylinositol 3-kinase (Akt),. Animal model experiments demonstrated accelerated bone repair, supporting the potential of HA/PDNFS@BMSCs-AP scaffolds for targeted bone defect healing. These findings highlight the promise of functionalized nanofibrous scaffolds in bone tissue engineering and their potential application in regenerative medicine and translational research.</p>

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Fabrication of BMSCs-affinity peptide functionalized blended hyaluronic acid/polydopamine nanofibrous scaffolds to controlled Mg ion release and improved osteogenic differentiations for accelerating bone regeneration

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月29日

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  • Jingzhe Zhang,
  • Xinkun Wang,
  • Xinbiao Fu,
  • Ye Li

摘要

Bone regeneration requires innovative solutions to enhance osteogenic differentiation and support effective tissue repair. This study presents a novel approach to bone tissue engineering by developing peptide-functionalized nanofibrous scaffolds (NFS). The fabrication of a blended hyaluronic acid (HA) and polydopamine (PD) scaffold functionalized with bone marrow mesenchymal stem cells (BMSCs)-affinity peptides (AP) designed to control magnesium ion (Mg) release, which supports BMSCs’ osteogenic differentiation and bone regeneration. Characterization studies, including fourier-transform infrared spectroscopy (FTIR) and morphological analysis, confirmed the hydrophilic properties of HA/PDNFS@BMSCs-AP scaffolds, which enhance cell adhesion and proliferation. In vitro and In vivo assessments revealed that the scaffolds significantly promote osteogenesis through AP-induced pathways such as extracellular signal-regulated kinase pathway (ERK) and Phosphatidylinositol 3-kinase (Akt),. Animal model experiments demonstrated accelerated bone repair, supporting the potential of HA/PDNFS@BMSCs-AP scaffolds for targeted bone defect healing. These findings highlight the promise of functionalized nanofibrous scaffolds in bone tissue engineering and their potential application in regenerative medicine and translational research.