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Background <p>Longitudinally extensive transverse myelitis (LETM) is a rare neurological disease. A case series evaluated the predictors of a long-term clinical outcome. However, there is limited data on predictors of functional status at presentation. Therefore, this study aimed to find clinical factors predictive of poor clinical presentation in Asian patients with LETM.</p> Methods <p>This was a cross-sectional, retrospective analytical study. The inclusion criteria were adult patients with an age of 18 years or more who met the criteria of LETM. Clinical factors of eligible patients were recorded. Eligible patients were categorized into two groups based on the Expanded Disability Status Scale (EDSS) at the time of presentation; 6 or more vs. 0-5.5. A predictive model for the EDSS score at the time of presentation was created by the logistic regression analysis.</p> Results <p>There were 40 patients with LETM in the study. Of those, 31 patients (77.50%) had an EDSS of 6 or more. There were two factors in the model predictive of the EDSS at presentation of 6 or more; thoracic lesion and complete lesion. Only a complete lesion was independently associated with an EDSS at presentation of 6 or more with an adjusted odds ratio of 15.202 (95% confidence interval of 2.028, 113.968; <i>p</i> value = 0.008).</p> Conclusions <p>The complete cord lesion was independently associated with severe functional status in patients with LETM at presentation.</p>

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Factors associated with functional status at presentation in patients with longitudinally extensive transverse myelitis

  • 期刊论文

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  • 发表日期：

    2025年9月2日

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  • Nisa Vorasoot,
  • Pilantana Saichua,
  • Prapassara Sirikarn,
  • Narongrit Kasemsap,
  • Kannikar Kongbunkiat,
  • Somsak Tiamkao,
  • Verajit Chotmongkol,
  • Kittisak Sawanyawisuth

摘要

Background

Longitudinally extensive transverse myelitis (LETM) is a rare neurological disease. A case series evaluated the predictors of a long-term clinical outcome. However, there is limited data on predictors of functional status at presentation. Therefore, this study aimed to find clinical factors predictive of poor clinical presentation in Asian patients with LETM.

Methods

This was a cross-sectional, retrospective analytical study. The inclusion criteria were adult patients with an age of 18 years or more who met the criteria of LETM. Clinical factors of eligible patients were recorded. Eligible patients were categorized into two groups based on the Expanded Disability Status Scale (EDSS) at the time of presentation; 6 or more vs. 0-5.5. A predictive model for the EDSS score at the time of presentation was created by the logistic regression analysis.

Results

There were 40 patients with LETM in the study. Of those, 31 patients (77.50%) had an EDSS of 6 or more. There were two factors in the model predictive of the EDSS at presentation of 6 or more; thoracic lesion and complete lesion. Only a complete lesion was independently associated with an EDSS at presentation of 6 or more with an adjusted odds ratio of 15.202 (95% confidence interval of 2.028, 113.968; p value = 0.008).

Conclusions

The complete cord lesion was independently associated with severe functional status in patients with LETM at presentation.