Purpose <p>To evaluate the feasibility of a modified fluoroscopy-guided percutaneous jejunostomy (PJ) technique incorporating a double-balloon catheter for segmental air trapping and stabilization of the jejunum in an ex vivo porcine model.</p> Materials and methods <p>An ex vivo porcine stomach–jejunum model was established to simulate human anatomy. A double-balloon catheter was introduced into the jejunum to isolate a target segment by inflating both balloons, allowing controlled air insufflation while reducing air leakage. Percutaneous jejunostomy was then performed using the proposed technique under fluoroscopic guidance. For comparison, procedural data from conventional fluoroscopy-guided PJ performed in the same ex vivo model without double-balloon assistance were analyzed.</p> Results <p>Ten fluoroscopy-guided PJ procedures were successfully completed using the proposed technique. Compared with the conventional approach, the modified technique required substantially less air for jejunal distension and was associated with shorter procedure time and reduced fluoroscopy time.</p> Conclusion <p>The proposed fluoroscopy-guided PJ technique incorporating double-balloon-assisted segmental isolation is feasible in an ex vivo porcine model. By facilitating localized air trapping and stabilization of the target jejunal segment, the technique may improve procedural efficiency and targeting accuracy compared with the conventional approach.</p>