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Background <p>Patients receiving clopidogrel who undergo urgent CABG before the recommended 5-day washout period are at increased risk of perioperative bleeding. This study evaluated whether intraoperative hemoadsorption can reduce bleeding in such patients.</p> Methods <p>Patients undergoing CABG within 24&#xa0;h of clopidogrel discontinuation were randomized 1:1 to intraoperative hemoadsorption (Group 1) or control (Group 2). In the intervention group, the device was incorporated into the cardiopulmonary bypass (CPB) circuit. Efficacy was assessed by 24-hour chest tube drainage (CTD), blood product transfusions and surgical revisions for bleeding control.</p> Results <p>A total of 50 patients were randomized (mean age 64 ± 8.6 years, 82% male). There were no differences in baseline characteristics between groups. Group 1 showed significantly reduced median 24-hr CTD of 300mL [250–400] vs. 500mL [400–700], <i>p</i> = 0.0003, transfusions of packed red blood cells 0 [0–1] vs. 1 [0–2] units, <i>p</i> = 0.047), fresh frozen plasma 0 [0–0] vs. 2 [2–3] units, <i>p</i> &lt; 0.0001) and platelets 0 [0–0] vs. 2 [1–3] units, <i>p</i> &lt; 0.0001 compared with Group 2. One revision for bleeding control occurred in Group 2 (4.0%). No device-related serious adverse events were observed.</p> Conclusion <p>In this cohort of clopidogrel-treated patients undergoing CABG within 24&#xa0;h of discontinuation, intraoperative hemoadsorption was associated with lower postoperative bleeding and transfusion requirements.</p>

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Randomized pilot trial of intraoperative hemoadsorption in clopidogrel treated patients undergoing urgent coronary artery bypass grafting

  • 期刊论文

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  • 发表日期：

    2026年7月27日

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  • Alireza Jahangirifard,
  • Seyed Bashir Mirtajani,
  • Is´haq Al-Aamri,
  • Kumait Al-Lawati,
  • Mandana Hosseinzadeh,
  • Daniel Wendt,
  • Efthymios N. Deliargyris,
  • Mohammad Hossein Mandegar

摘要

Background

Patients receiving clopidogrel who undergo urgent CABG before the recommended 5-day washout period are at increased risk of perioperative bleeding. This study evaluated whether intraoperative hemoadsorption can reduce bleeding in such patients.

Methods

Patients undergoing CABG within 24 h of clopidogrel discontinuation were randomized 1:1 to intraoperative hemoadsorption (Group 1) or control (Group 2). In the intervention group, the device was incorporated into the cardiopulmonary bypass (CPB) circuit. Efficacy was assessed by 24-hour chest tube drainage (CTD), blood product transfusions and surgical revisions for bleeding control.

Results

A total of 50 patients were randomized (mean age 64 ± 8.6 years, 82% male). There were no differences in baseline characteristics between groups. Group 1 showed significantly reduced median 24-hr CTD of 300mL [250–400] vs. 500mL [400–700], p = 0.0003, transfusions of packed red blood cells 0 [0–1] vs. 1 [0–2] units, p = 0.047), fresh frozen plasma 0 [0–0] vs. 2 [2–3] units, p < 0.0001) and platelets 0 [0–0] vs. 2 [1–3] units, p < 0.0001 compared with Group 2. One revision for bleeding control occurred in Group 2 (4.0%). No device-related serious adverse events were observed.

Conclusion

In this cohort of clopidogrel-treated patients undergoing CABG within 24 h of discontinuation, intraoperative hemoadsorption was associated with lower postoperative bleeding and transfusion requirements.