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<p>Antiphospholipid syndrome (APS), characterized by antiphospholipid antibody (aPL)-driven thrombosis, is increasingly recognized as a critical etiology of catastrophic coronary events in young adults lacking traditional cardiovascular risk factors. This report delineates a 24-year-old male with left main coronary artery (LMCA) ST-segment elevation myocardial infarction (STEMI), managed through a novel strategy combining drug-coated balloon (DCB) angioplasty and APS-targeted pharmacotherapy (anticoagulation and immunomodulation). The case underscores the necessity of etiological exploration in young STEMI populations and challenges the conventional stent-based revascularization paradigm in hypercoagulable states. One-year follow-up demonstrated sustained patency without recurrent thrombosis, validating the efficacy of pathophysiology-guided interventions.</p>

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Drug-coated balloon angioplasty for catastrophic left main STEMI in a 24-year-old with antiphospholipid syndrome: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月21日

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  • Yufeng Jiang,
  • Feifei Cui,
  • Liangping Zhao,
  • Yafeng Zhou

摘要

Antiphospholipid syndrome (APS), characterized by antiphospholipid antibody (aPL)-driven thrombosis, is increasingly recognized as a critical etiology of catastrophic coronary events in young adults lacking traditional cardiovascular risk factors. This report delineates a 24-year-old male with left main coronary artery (LMCA) ST-segment elevation myocardial infarction (STEMI), managed through a novel strategy combining drug-coated balloon (DCB) angioplasty and APS-targeted pharmacotherapy (anticoagulation and immunomodulation). The case underscores the necessity of etiological exploration in young STEMI populations and challenges the conventional stent-based revascularization paradigm in hypercoagulable states. One-year follow-up demonstrated sustained patency without recurrent thrombosis, validating the efficacy of pathophysiology-guided interventions.