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Objective <p>No studies have been reported on the associations between the polymorphisms and mutations of rs11573819, rs2073618, and rs3102735 loci in osteoprotegerin (OPG) gene and bone metabolism in postmenopausal women in Shihezi, Xinjiang. Therefore, this study aimed to investigate the relationship between the polymorphisms and mutations of these three OPG gene loci and bone metabolism in postmenopausal women in this region.</p> Methods <p>This study enrolled 200 postmenopausal women who were divided into two groups based on the results of bone mineral density (BMD): the normal bone mineral density group (NBM group) and the low bone mineral density group (LBM group). Baseline data, biochemical indicators, BMD and other information of the subjects were collected and compared. The polymorphisms of OPG loci were determined by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS).</p> Results <p>(1) Compared with the NBM group, the LBM group had higher mean age, longer menopausal years and elevated TyG index, while lower levels of HDL and BMD (L<sub>1-4</sub> and femoral neck). (2) At the rs2073618 locus, there was a statistically significant difference in genotype distribution between the two groups. (3) After multiple testing correction using the Benjamini–Hochberg method, at the rs11573819 locus: Compared with the GG genotype (wild type), the AA/GA genotypes (mutant type) in the NBM group had lower levels of BMD (L<sub>1-4</sub> and femoral neck), and the AA/GA genotypes (mutant type) in the LBM group had lower levels of BMD (femoral neck). (4) Multiple linear regression analysis: For BMD (L<sub>1-4</sub>), the influencing factors included menopausal years, WHR, FPG, LDL, HDL, TyG index, AST, and the mutation of rs11573819 locus. For BMD (femoral neck), the influencing factors included menopausal years, LDL, HDL, and the mutation of rs11573819 locus.</p> Conclusion <p>The polymorphism of OPG gene rs2073618 locus and the mutation of OPG gene rs11573819 locus may be associated with bone metabolism in postmenopausal women in Shihezi, Xinjiang.</p>

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The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Jun Li,
  • Chuanbing Sun,
  • Siyuan Li,
  • Ya Li,
  • Yujuan Shen,
  • Hangning Tian

摘要

Objective

No studies have been reported on the associations between the polymorphisms and mutations of rs11573819, rs2073618, and rs3102735 loci in osteoprotegerin (OPG) gene and bone metabolism in postmenopausal women in Shihezi, Xinjiang. Therefore, this study aimed to investigate the relationship between the polymorphisms and mutations of these three OPG gene loci and bone metabolism in postmenopausal women in this region.

Methods

This study enrolled 200 postmenopausal women who were divided into two groups based on the results of bone mineral density (BMD): the normal bone mineral density group (NBM group) and the low bone mineral density group (LBM group). Baseline data, biochemical indicators, BMD and other information of the subjects were collected and compared. The polymorphisms of OPG loci were determined by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS).

Results

(1) Compared with the NBM group, the LBM group had higher mean age, longer menopausal years and elevated TyG index, while lower levels of HDL and BMD (L1-4 and femoral neck). (2) At the rs2073618 locus, there was a statistically significant difference in genotype distribution between the two groups. (3) After multiple testing correction using the Benjamini–Hochberg method, at the rs11573819 locus: Compared with the GG genotype (wild type), the AA/GA genotypes (mutant type) in the NBM group had lower levels of BMD (L1-4 and femoral neck), and the AA/GA genotypes (mutant type) in the LBM group had lower levels of BMD (femoral neck). (4) Multiple linear regression analysis: For BMD (L1-4), the influencing factors included menopausal years, WHR, FPG, LDL, HDL, TyG index, AST, and the mutation of rs11573819 locus. For BMD (femoral neck), the influencing factors included menopausal years, LDL, HDL, and the mutation of rs11573819 locus.

Conclusion

The polymorphism of OPG gene rs2073618 locus and the mutation of OPG gene rs11573819 locus may be associated with bone metabolism in postmenopausal women in Shihezi, Xinjiang.