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Background <p>Magnetic resonance (MR) imaging-linear accelerator-based real-time adaptive planning for delivering ultra-hypofractionated stereotactic body radiotherapy (SBRT) has advanced clinical accuracy yet added complexity to the radiotherapy workflow. We retrospectively evaluated whether the addition of a Parallel Automated Contouring module with Enhancement of AI (PACE-AI) reduced contouring time and overall SBRT duration, and its impact on intra-fractional target motion.</p> Methods <p>This study included 250 fractions from 90 prostate cancer patients from which fraction time were tracked. All patients received definitive SBRT to the prostate on the 1.5-Tesla Unity (Elekta©) system, through the Adapt-To-Shape (ATS) workflow, which required real-time re-contouring of the normal tissues by the dosimetrists and target contouring by the physician for each of the fractions. We compared the fraction durations for 125 consecutive fractions treated with the incorporation of PACE-AI with 125 fractions previously treated without PACE-AI to determine whether PACE-AI improved efficiency and reduced treatment session duration.</p> Results <p>For the cohort treated without PACE-AI, the overall median duration was 67.6&#xa0;min, including 23.9&#xa0;min contouring time. With the incorporation of PACE-AI, the overall median duration was 51.2&#xa0;min, representing a 24.3% reduction. The average contouring time was reduced by 55% to 10.8&#xa0;min. In addition, the extent of positional shifts prior to beam delivery was significantly reduced from an average of 1.8&#xa0;mm to 1.3&#xa0;mm (<i>p</i> &lt; 0.001) in both superior/inferior (range reduced from 0 to 6.3&#xa0;mm to 0–4.2&#xa0;mm) and anterior/posterior directions (range reduced from 0 to 6.6&#xa0;mm to 0–5.0&#xa0;mm).</p> Conclusions <p>The incorporation of PACE-AI improved workflow efficiency during SBRT. The reduction in treatment duration also helped reduce organ motion during real-time adaptive planning.</p>

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Improving workflow efficiency during prostate stereotactic body radiotherapy using real-time adaptive planning associated with reduced intra-fractional target motion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月28日

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  • Ting Chen,
  • David Barbee,
  • Hesheng Wang,
  • Siming Lu,
  • Sangkyu Lee,
  • Ruth Afanador,
  • Stavroula Kolitsopoulos,
  • Matthew Long,
  • Allison McCarthy,
  • Paulina Galavis,
  • Peter Schiff,
  • Michael J Zelefsky

摘要

Background

Magnetic resonance (MR) imaging-linear accelerator-based real-time adaptive planning for delivering ultra-hypofractionated stereotactic body radiotherapy (SBRT) has advanced clinical accuracy yet added complexity to the radiotherapy workflow. We retrospectively evaluated whether the addition of a Parallel Automated Contouring module with Enhancement of AI (PACE-AI) reduced contouring time and overall SBRT duration, and its impact on intra-fractional target motion.

Methods

This study included 250 fractions from 90 prostate cancer patients from which fraction time were tracked. All patients received definitive SBRT to the prostate on the 1.5-Tesla Unity (Elekta©) system, through the Adapt-To-Shape (ATS) workflow, which required real-time re-contouring of the normal tissues by the dosimetrists and target contouring by the physician for each of the fractions. We compared the fraction durations for 125 consecutive fractions treated with the incorporation of PACE-AI with 125 fractions previously treated without PACE-AI to determine whether PACE-AI improved efficiency and reduced treatment session duration.

Results

For the cohort treated without PACE-AI, the overall median duration was 67.6 min, including 23.9 min contouring time. With the incorporation of PACE-AI, the overall median duration was 51.2 min, representing a 24.3% reduction. The average contouring time was reduced by 55% to 10.8 min. In addition, the extent of positional shifts prior to beam delivery was significantly reduced from an average of 1.8 mm to 1.3 mm (p < 0.001) in both superior/inferior (range reduced from 0 to 6.3 mm to 0–4.2 mm) and anterior/posterior directions (range reduced from 0 to 6.6 mm to 0–5.0 mm).

Conclusions

The incorporation of PACE-AI improved workflow efficiency during SBRT. The reduction in treatment duration also helped reduce organ motion during real-time adaptive planning.