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Background <p>The TaiChi radiotherapy platform is an innovative system integrating linear accelerator (LINAC) and Gamma Knife technologies, approved by both NMPA and FDA. This hybrid design enables bimodal (X-ray and γ-ray) radiation delivery, offering enhanced flexibility for treatment planning and dose delivery. This study quantitatively evaluates its dosimetric performance for lattice radiotherapy (LRT) in soft tissue sarcoma (STS), specifically comparing its dose escalation potential and normal tissue sparing to conventional C-arm LINAC.</p> Methods <p>A dosimetric analysis was conducted on 10 STS cases. The treatment combined LRT (15&#xa0;Gy single fraction to spherical vertices within the Gross tumor volume (GTV)) with conventionally fractionated external beam radiotherapy (50&#xa0;Gy/25F to the planning target volume (PTV)). TaiChi utilized its dual-modality capability, employing γ-ray focusing for vertex dose escalation and optimizing the LINAC for conventional coverage. Plans were compared on high-dose vertex coverage, dose fall-off, and organ-at-risk (OAR) sparing.</p> Results <p>TaiChi demonstrated superior dosimetric performance across all evaluated parameters. For vertex coverage, TaiChi achieved significantly higher D<sub>0.5cc</sub> (25.15 ± 0.39&#xa0;Gy vs. 18.90 ± 0.44&#xa0;Gy, <i>p</i> &lt; 0.0001) and D<sub>mean</sub> (18.87 ± 0.46&#xa0;Gy vs. 16.66 ± 0.85&#xa0;Gy, <i>p</i> &lt; 0.0001). Dose gradient analysis revealed steeper fall-off with TaiChi, evidenced by higher GTV D<sub>10</sub>/D<sub>90</sub> values (5.93 ± 0.84 vs. 3.40 ± 0.92, <i>p</i> &lt; 0.0001) and reduced margin doses (3.95 ± 0.48&#xa0;Gy vs. 4.87 ± 0.41&#xa0;Gy, <i>p</i> &lt; 0.0001). Importantly, these improvements were achieved while maintaining or reducing OAR exposure, with statistically reductions in maximum doses to nerves and bones (<i>p</i> &lt; 0.05).</p> Conclusion <p>The TaiChi platform’s innovative integration of LINAC and Gamma Knife technologies provides distinct dosimetric advantages for STS LRT, enabling superior dose escalation to high-dose vertex regions while maintaining steep dose gradients and effective normal tissue sparing. These capabilities position TaiChi as a promising platform for advancing LRT applications.</p> Clinical trial number <p>Not applicable.</p>

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A novel strategy for soft tissue sarcoma lattice radiotherapy: integrating X-ray andγ-ray technologies to optimize dose delivery

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Zhongfei Wang,
  • Qinghui Yun,
  • Te Zhang,
  • Xiaohuan Sun,
  • Wei Wang,
  • Jie Duan,
  • Liting Chen,
  • Yue Gao,
  • Ziqi An,
  • Changhao Liu,
  • Jian Zang,
  • Pengfei Zhang,
  • Lina Zhao

摘要

Background

The TaiChi radiotherapy platform is an innovative system integrating linear accelerator (LINAC) and Gamma Knife technologies, approved by both NMPA and FDA. This hybrid design enables bimodal (X-ray and γ-ray) radiation delivery, offering enhanced flexibility for treatment planning and dose delivery. This study quantitatively evaluates its dosimetric performance for lattice radiotherapy (LRT) in soft tissue sarcoma (STS), specifically comparing its dose escalation potential and normal tissue sparing to conventional C-arm LINAC.

Methods

A dosimetric analysis was conducted on 10 STS cases. The treatment combined LRT (15 Gy single fraction to spherical vertices within the Gross tumor volume (GTV)) with conventionally fractionated external beam radiotherapy (50 Gy/25F to the planning target volume (PTV)). TaiChi utilized its dual-modality capability, employing γ-ray focusing for vertex dose escalation and optimizing the LINAC for conventional coverage. Plans were compared on high-dose vertex coverage, dose fall-off, and organ-at-risk (OAR) sparing.

Results

TaiChi demonstrated superior dosimetric performance across all evaluated parameters. For vertex coverage, TaiChi achieved significantly higher D0.5cc (25.15 ± 0.39 Gy vs. 18.90 ± 0.44 Gy, p < 0.0001) and Dmean (18.87 ± 0.46 Gy vs. 16.66 ± 0.85 Gy, p < 0.0001). Dose gradient analysis revealed steeper fall-off with TaiChi, evidenced by higher GTV D10/D90 values (5.93 ± 0.84 vs. 3.40 ± 0.92, p < 0.0001) and reduced margin doses (3.95 ± 0.48 Gy vs. 4.87 ± 0.41 Gy, p < 0.0001). Importantly, these improvements were achieved while maintaining or reducing OAR exposure, with statistically reductions in maximum doses to nerves and bones (p < 0.05).

Conclusion

The TaiChi platform’s innovative integration of LINAC and Gamma Knife technologies provides distinct dosimetric advantages for STS LRT, enabling superior dose escalation to high-dose vertex regions while maintaining steep dose gradients and effective normal tissue sparing. These capabilities position TaiChi as a promising platform for advancing LRT applications.

Clinical trial number

Not applicable.