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Background <p>Stereotactic body radiotherapy (SBRT) is applied for both primary liver tumours and liver metastases. Within a national project, we investigated patterns of care for liver SBRT and factors influencing local control (LC) and overall survival (OS).</p> Methods <p>Patients treated with SBRT were prospectively registered within a quality assurance project. Patient- and tumour-related factors, and data on use of markers, personalised immobilisation, image guidance and radiotherapy techniques were collected. OS and LC were evaluated by Kaplan-Meier analysis and Cox proportional hazard models.</p> Results <p>From August 2013 to December 2019, fourteen centres treated 352 patients with SBRT for a total of 408 lesions (66 primary, 342 metastases). Colorectal adenocarcinoma was the most common primary cancer (<i>n</i> = 170, 42%). A gradual uptake of SBRT and increasing prescription dose were observed over time. One, 2- and 5- year OS probabilities were 74.3%, 49.7% and 19.4%. LC data were available for 354 lesions. LC probabilities at 1-, 2- and 5-years were 69.9%, 52.2% and 32.4%. Better OS and LC were found for patients with smaller PTV volumes and higher BED10. Patients with better performance status had a better OS. A better LC was observed in patients who were not priorly treated with systemic therapy.</p> Conclusions <p>We observed an increase in liver SBRT uptake and a reasonable LC and OS. Higher BED10 and smaller PTV volumes translated into high local tumour control and survival. After correction of patient case-mix, none of the technical parameters showed a significant association with outcome.</p> Trial registration <p>Not applicable, this is a retrospective analysis of data that were prospectively registered as part of a national quality assurance programme of the Belgian Cancer Registry.</p>

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Patterns of care and outcome of liver SBRT: results from a multicentre National quality project

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Pieter Deseyne,
  • Geert Silversmit,
  • Nicolas Jansen,
  • Yolande Lievens,
  • Luigi Moretti,
  • Sara Van Brussel,
  • Katleen Verboven,
  • Philippe Bulens,
  • Stephanie Deheneffe,
  • Jean-François Rosier,
  • Samuel Bral,
  • Sophie Cvilic,
  • Mark De Ridder,
  • Karin Haustermans,
  • Geneviève Van Ooteghem,
  • Karin Stellamans,
  • Nancy Van Damme,
  • Reinhilde Weytjens,
  • Ines Joye

摘要

Background

Stereotactic body radiotherapy (SBRT) is applied for both primary liver tumours and liver metastases. Within a national project, we investigated patterns of care for liver SBRT and factors influencing local control (LC) and overall survival (OS).

Methods

Patients treated with SBRT were prospectively registered within a quality assurance project. Patient- and tumour-related factors, and data on use of markers, personalised immobilisation, image guidance and radiotherapy techniques were collected. OS and LC were evaluated by Kaplan-Meier analysis and Cox proportional hazard models.

Results

From August 2013 to December 2019, fourteen centres treated 352 patients with SBRT for a total of 408 lesions (66 primary, 342 metastases). Colorectal adenocarcinoma was the most common primary cancer (n = 170, 42%). A gradual uptake of SBRT and increasing prescription dose were observed over time. One, 2- and 5- year OS probabilities were 74.3%, 49.7% and 19.4%. LC data were available for 354 lesions. LC probabilities at 1-, 2- and 5-years were 69.9%, 52.2% and 32.4%. Better OS and LC were found for patients with smaller PTV volumes and higher BED10. Patients with better performance status had a better OS. A better LC was observed in patients who were not priorly treated with systemic therapy.

Conclusions

We observed an increase in liver SBRT uptake and a reasonable LC and OS. Higher BED10 and smaller PTV volumes translated into high local tumour control and survival. After correction of patient case-mix, none of the technical parameters showed a significant association with outcome.

Trial registration

Not applicable, this is a retrospective analysis of data that were prospectively registered as part of a national quality assurance programme of the Belgian Cancer Registry.