Scholarlink

Background <p>This study aimed to investigate the progression of taste dysfunction (TD) in patients with head and neck cancer (HNC) receiving radiotherapy (RT) and to develop a normal tissue complication probability (NTCP) model for predicting TD.</p> Methods <p>A cross-sectional study was conducted on August 23rd and 24th, 2023. Eligible participants included newly diagnosed, pathologically confirmed HNC patients without distant metastasis. Acute toxicities were assessed via the NCI CTCAE v5.0, and taste acuity was evaluated via the Subjective Total Taste Acuity (STTA) Scale. Radiation dose data for organs at risk (OARs) were collected. Descriptive statistics and multivariate logistic regression were employed to develop the NTCP models.</p> Results <p>Among the 444 participants, 265 (60%) experienced TD with a CTCAE grade ≥ 2. Acute TD was significantly associated with body mass index (BMI) (OR: 0.936, <i>P</i> = 0.029). The mean dose (Dmean) of the parotid glands was the most predictive factor (AUC: 0.72) for acute TD. The tolerance dose of 50% for the parotid glands to develop acute TD ≥ 2 during RT was 24&#xa0;Gy. The Dmean of the parotid glands to the predicted 10%, 30% and 50% probabilities of long-term TD were 45, 78 and 94&#xa0;Gy after 3 months and 80, 97 and 105&#xa0;Gy after 6 months, respectively.</p> Conclusions <p>A lower BMI was significantly associated with TD, and a significant correlation was observed between TD and quality of life (QoL). The incidence of TD is closely related to the radiation dose, and reducing the dose to the parotid glands can lower the risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dose-dependent taste dysfunction in head and neck cancer patients receiving radiotherapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月4日

查看全文
  • Su-Man Zhang,
  • Feng-Yan Li,
  • Meng-Yu Hao,
  • Yu-Xian Yang,
  • Yu-Xi Xiong,
  • Yao-Zhuang Chuah,
  • Feng Chi,
  • Guang-Yu Wang,
  • Li-Ping Qi,
  • Dan Zhou,
  • Le-Cheng Jia,
  • Hua Li,
  • Yan-Fei Liu,
  • Ying Sun,
  • Rui Guo,
  • Guan-Qun Zhou

摘要

Background

This study aimed to investigate the progression of taste dysfunction (TD) in patients with head and neck cancer (HNC) receiving radiotherapy (RT) and to develop a normal tissue complication probability (NTCP) model for predicting TD.

Methods

A cross-sectional study was conducted on August 23rd and 24th, 2023. Eligible participants included newly diagnosed, pathologically confirmed HNC patients without distant metastasis. Acute toxicities were assessed via the NCI CTCAE v5.0, and taste acuity was evaluated via the Subjective Total Taste Acuity (STTA) Scale. Radiation dose data for organs at risk (OARs) were collected. Descriptive statistics and multivariate logistic regression were employed to develop the NTCP models.

Results

Among the 444 participants, 265 (60%) experienced TD with a CTCAE grade ≥ 2. Acute TD was significantly associated with body mass index (BMI) (OR: 0.936, P = 0.029). The mean dose (Dmean) of the parotid glands was the most predictive factor (AUC: 0.72) for acute TD. The tolerance dose of 50% for the parotid glands to develop acute TD ≥ 2 during RT was 24 Gy. The Dmean of the parotid glands to the predicted 10%, 30% and 50% probabilities of long-term TD were 45, 78 and 94 Gy after 3 months and 80, 97 and 105 Gy after 6 months, respectively.

Conclusions

A lower BMI was significantly associated with TD, and a significant correlation was observed between TD and quality of life (QoL). The incidence of TD is closely related to the radiation dose, and reducing the dose to the parotid glands can lower the risk.