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Background <p>Lymphorrhea is a complication that can arise after vascular, abdominal or pelvic interventions and is associated with significant morbidity. While conservative management is typically effective, some cases remain refractory.</p> Methods <p>This retrospective cross-sectional study analyzed 43 patients with persistent inguinal lymphorrhea treated at a tertiary hospital between 2008 and 2018. All patients received external beam radiotherapy (EBRT) using 3D conformal techniques with photons (6–18 MV). The delivered dose was 7.5 Gy in five 1,5 Gy/fractions.</p> Results <p>Complete closure of the lymphatic fistula was achieved in all patients. Three required reirradiation with the same schedule to reach complete resolution. No acute or late toxicity was observed in any case.</p> Conclusions <p>Low-dose EBRT is a safe and effective treatment option for persistent lymphorrhea refractory to conservative measures. Its anti-inflammatory and fibrosing effects support its therapeutic use in benign lymphatic complications.</p> Trial registration <p>Not applicable.</p>

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Low-dose radiotherapy for benign conditions: management of persistent inguinal lymphorrea

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月20日

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  • Verónica Cañón,
  • Javier Anchuelo,
  • Claudia Laborda,
  • Ana Galán,
  • Ana Laura Rivero,
  • Frandeína Pinto,
  • Mara García,
  • Paola Navarrete,
  • Piedad Galdós,
  • Ana Aliaga,
  • Arantxa Ayete Andreu,
  • Cristina García,
  • Gemma Liria,
  • Maria Cerrolaza,
  • Rosa Fabregat,
  • Claudia Colom Pla,
  • Pedro José Prada

摘要

Background

Lymphorrhea is a complication that can arise after vascular, abdominal or pelvic interventions and is associated with significant morbidity. While conservative management is typically effective, some cases remain refractory.

Methods

This retrospective cross-sectional study analyzed 43 patients with persistent inguinal lymphorrhea treated at a tertiary hospital between 2008 and 2018. All patients received external beam radiotherapy (EBRT) using 3D conformal techniques with photons (6–18 MV). The delivered dose was 7.5 Gy in five 1,5 Gy/fractions.

Results

Complete closure of the lymphatic fistula was achieved in all patients. Three required reirradiation with the same schedule to reach complete resolution. No acute or late toxicity was observed in any case.

Conclusions

Low-dose EBRT is a safe and effective treatment option for persistent lymphorrhea refractory to conservative measures. Its anti-inflammatory and fibrosing effects support its therapeutic use in benign lymphatic complications.

Trial registration

Not applicable.