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Background <p>Invitation letters can be the first point of contact between research staff and potential participants and a number of modifiable variables have been studied to improve their effectiveness. The aim of this analysis was to determine if lower reading levels and “gain-framed” messages improved recruitment for a RCT that mailed nicotine replacement therapy (NRT) patches for smoking cessation.</p> Methods <p>Invitation letters were created which varied in a two-by-two design by reading level and message framing. The letters were randomly mailed to all households in a community selected to receive targeted distribution of NRT patches.</p> Results <p>There were no significant differences found in the number of participants enrolled.</p> Conclusion <p>Future research investigating factors to improve invitation letters is merited despite current project limitations.</p> Trial registration <p>ClinicalTrials.gov NCT04534231.</p>

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Investigating if changing the wording of a study invitation letter increased recruitment in a project promoting tobacco cessation in a town with high smoking rates

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月27日

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  • Christina Schell,
  • Alexandra Godinho,
  • John A. Cunningham

摘要

Background

Invitation letters can be the first point of contact between research staff and potential participants and a number of modifiable variables have been studied to improve their effectiveness. The aim of this analysis was to determine if lower reading levels and “gain-framed” messages improved recruitment for a RCT that mailed nicotine replacement therapy (NRT) patches for smoking cessation.

Methods

Invitation letters were created which varied in a two-by-two design by reading level and message framing. The letters were randomly mailed to all households in a community selected to receive targeted distribution of NRT patches.

Results

There were no significant differences found in the number of participants enrolled.

Conclusion

Future research investigating factors to improve invitation letters is merited despite current project limitations.

Trial registration

ClinicalTrials.gov NCT04534231.