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Background <p>Primary cutaneous diffuse large B-cell lymphoma, leg type(PCDLBCL-LT) is a rare form of lymphoma that originates from the post-germinal center and typically does not express terminal deoxynucleotidyl transferase(TdT), a marker of immunophenotypic immaturity.</p> Case description <p>A 73-year-old female presented to our hospital with recurrent nodules on her lower limbs, which had persisted for over five years without systemic involvement, accompanied by a gradual increase in TdT expression. Histology revealed diffuse infiltration of centroblasts and/or immunoblasts within the dermis and subcutis, with CD20, CD10, BCL2 and c-MYC expression. Fluorescence in situ hybridization (FISH) showed <i>MYC</i> rearrangement without <i>BCL2</i>/<i>BCL6</i> alterations, corroborating the diagnosis of TdT-positive PCDLBCL-LT. Following six cycle of R-CHOP chemotherapy, the patient achieved complete remission. A follow-up conducted one year showed no tumor recurrence.</p> Conclusion <p>Our case showed that TdT can be expressed in PCDLBCL-LT, and highlight the importance of a comprehensive analysis of clinicopathology and ancillary testing to avoid misdiagnosis. Additionally, the clinical course of TdT-positive PCDLBCL-LT seems remain relatively favorable. However, further research is still needed on this relationship.</p>

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Case report: a case of primary cutaneous diffuse large B-cell lymphoma, leg type with TdT positive in an elderly woman

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  • 发表日期：

    2026年4月1日

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  • Jingwei Zheng,
  • Xinghui Li,
  • Hao Chen

摘要

Background

Primary cutaneous diffuse large B-cell lymphoma, leg type(PCDLBCL-LT) is a rare form of lymphoma that originates from the post-germinal center and typically does not express terminal deoxynucleotidyl transferase(TdT), a marker of immunophenotypic immaturity.

Case description

A 73-year-old female presented to our hospital with recurrent nodules on her lower limbs, which had persisted for over five years without systemic involvement, accompanied by a gradual increase in TdT expression. Histology revealed diffuse infiltration of centroblasts and/or immunoblasts within the dermis and subcutis, with CD20, CD10, BCL2 and c-MYC expression. Fluorescence in situ hybridization (FISH) showed MYC rearrangement without BCL2/BCL6 alterations, corroborating the diagnosis of TdT-positive PCDLBCL-LT. Following six cycle of R-CHOP chemotherapy, the patient achieved complete remission. A follow-up conducted one year showed no tumor recurrence.

Conclusion

Our case showed that TdT can be expressed in PCDLBCL-LT, and highlight the importance of a comprehensive analysis of clinicopathology and ancillary testing to avoid misdiagnosis. Additionally, the clinical course of TdT-positive PCDLBCL-LT seems remain relatively favorable. However, further research is still needed on this relationship.